通过明胶水凝胶局部控释基质细胞衍生因子 1α 和全身给药高迁移率基团框 1 肽促进气管软骨再生

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.06.017

Kumiko (Ogi) Suzuki , Tatsuya Okamoto , Katsuto Tamai , Yasuhiko Tabata , Etsuro Hatano

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引用次数: 0

摘要

引言本研究评估了基质细胞衍生因子 1α（SDF-1α）和高迁移率基团框 1（HMGB1）肽联合疗法对大鼠气管损伤再生的影响。方法为了提高疗效，将 SDF-1α 加入明胶水凝胶中，然后将其涂在大鼠受损的气管软骨上进行局部释放。此外，还反复静脉注射 HMGB1 肽。结果具有 C-X-C motif趋化因子受体 4（CXCR4）的间充质干细胞（MSC）被更多地动员到损伤区域，因此在损伤八周后，联合疗法组的气管软骨再生速度最快。结论本研究表明，静脉注射含有SDF-1α和HMGB1肽的明胶水凝胶联合疗法可增强CXCR4阳性间充质干细胞的募集，促进受损气管软骨的再生。

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Enhancement of tracheal cartilage regeneration by local controlled release of stromal cell-derived factor 1α with gelatin hydrogels and systemic administration of high-mobility group box 1 peptide

Introduction

This present study evaluated the effect of combination therapy with stromal cell-derived factor 1α (SDF-1α) and high-mobility group box 1 (HMGB1) peptide on the regeneration of tracheal injury in a rat model.

Methods

To improve this effect, SDF-1α was incorporated into a gelatin hydrogel, which was then applied to the damaged tracheal cartilage of rats for local release. Furthermore, HMGB1 peptide was repeatedly administered intravenously. Regeneration of damaged tracheal cartilage was evaluated in terms of cell recruitment.

Results

Mesenchymal stem cells (MSC) with C-X-C motif chemokine receptor 4 (CXCR4) were mobilized more into the injured area, and consequently the fastest tracheal cartilage regeneration was observed in the combination therapy group eight weeks after injury.

Conclusions

The present study demonstrated that combination therapy with gelatin hydrogel incorporating SDF-1α and HMGB1 peptide injected intravenously can enhance the recruitment of CXCR4-positive MSC, promoting the regeneration of damaged tracheal cartilage.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.