Ning Yang , Tengfei Ma , Wenzhi Wang , Jiaxuan Sun , Xianzuo Zhang , Jinming Hu , Chen Zhu
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引用次数: 0
摘要
化脓性关节炎(SA)和类风湿性关节炎(RA)是流行且具有挑战性的关节疾病,通常会导致严重后果,包括败血症、残疾和危及生命。然而,它们不同的病因和病理机制需要不同的治疗策略。我们在此报告了一种一氧化碳(CO)释放胶束的单一配方,它能有效治疗 SA 和 RA 疾病。我们的研究结果表明,在红光刺激下局部释放一氧化碳能有效消灭耐甲氧西林金黄色葡萄球菌(MRSA)病原体,同时保护受 MRSA 感染的软骨细胞和成骨细胞。此外,二氧化碳的释放还能通过核因子红细胞-2相关因子(Nrf2)/血红素氧合酶-1(HO-1)途径协调巨噬细胞的极化平衡,从而表现出独特的抗炎和抗破骨细胞作用。这些非凡的特性使二氧化碳释放胶束成为一种独特的治疗方法,可在小鼠模型中同时治疗SA和RA,而无需使用抗生素和非甾体抗炎药(NSAID)等传统药物。
Carbon monoxide (CO)-releasing micelles enable efficient treatment of MRSA-induced septic arthritis and rheumatoid arthritis
Septic arthritis (SA) and rheumatoid arthritis (RA) are prevalent and challenging joint diseases that often lead to severe consequences, including sepsis, disability, and life-threatening conditions. However, their distinct etiologies and pathological mechanisms require different treatment strategies. We herein report a single formulation of carbon monoxide (CO)-releasing micelles capable of efficient treatment of both SA and RA diseases. Our findings demonstrate that the local release of CO under red light stimulus effectively eradicates methicillin-resistant Staphylococcus aureus (MRSA) pathogens while safeguarding MRSA-infected chondrocytes and osteogenic cells. Furthermore, CO delivery orchestrates macrophage polarization homeostasis via the nuclear factor erythroid-2-related factor (Nrf2)/heme oxygenase-1 (HO-1) pathway, manifesting unique anti-inflammatory and anti-osteoclastic effects. These remarkable properties empower CO-releasing micelles to emerge as a singular treatment approach, addressing both SA and RA in murine models without the need for conventional medications such as antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs).
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.