偏头痛与痴呆症之间因果关系的遗传学证据:亡羊补牢式随机研究。

IF 2.1 4区 医学 Q3 GENETICS & HEREDITY
Qiuyi Chen, Chengcheng Zhang, Shiyang Wu, Yiwei He, Yuhan Liu, Libin Zheng, Bin Li, Guiyou Liu, Lu Liu
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引用次数: 0

摘要

背景:偏头痛与痴呆之间存在关联,但其因果关系仍不清楚。本研究采用双向双样本孟德尔随机法(MR)调查偏头痛与痴呆症及其亚型之间的潜在因果关系:偏头痛与痴呆及其亚型(阿尔茨海默病(AD)、血管性痴呆(VaD)、额颞叶痴呆(FTD)和路易体痴呆(DLB))之间的潜在因果关系:从公开的全基因组关联研究(GWAS)中获得了偏头痛和五种类型痴呆的汇总级统计数据。筛选出与偏头痛和每种痴呆亚型相关的单核苷酸多态性(SNPs)。采用逆方差加权法(IVW)和加权中位数法(WM)进行了磁共振分析。敏感性分析包括Cochran's Q检验、MR多向性残差和离群值(MR-PRESSO)分析、MR-Egger截距和leave-one-out分析:结果:偏头痛与AD和VaD有明显的因果关系,而与全因痴呆、FTD或DLB则无因果关系。偏头痛可能是注意力缺失症的潜在风险因素(几率比 [OR]:1.09;95% 置信区间 [CI]:0.02-0.14;P = 0.007),而失智症可能是偏头痛的潜在风险因素(OR:1.04;95% 置信区间 [CI]:0.02-0.06;P = 7.760E-5)。敏感性分析表明我们的研究结果是可靠的:我们的研究表明,偏头痛可能与注意力缺失症和失智症有潜在的因果关系。偏头痛可能是AD的风险因素,而VaD可能是偏头痛的风险因素。我们的研究有助于揭示偏头痛与各种痴呆症之间的全面遗传关联,我们的研究结果将加深学术界对偏头痛与痴呆症并发症的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic evidence for causal association between migraine and dementia: a mendelian randomization study.

Background: There is an association between migraine and dementia, however, their causal relationship remains unclear. This study employed bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal relationship between migraine and dementia and its subtypes: Alzheimer's disease (AD), vascular dementia (VaD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).

Methods: Summary-level statistics data were obtained from publicly available genome-wide association studies (GWAS) for both migraine and five types of dementia. Single nucleotide polymorphisms (SNPs) associated with migraine and each dementia subtype were selected. MR analysis was conducted using inverse variance weighting (IVW) and weighted median (WM) methods. Sensitivity analyses included Cochran's Q test, MR pleiotropy residual sum and outlier (MR-PRESSO) analysis, the intercept of MR-Egger, and leave-one-out analysis.

Results: Migraine showed a significant causal relationship with AD and VaD, whereas no causal relationship was observed with all-cause dementia, FTD, or DLB. Migraine may be a potential risk factor for AD (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 0.02-0.14; P = 0.007), while VaD may be a potential risk factor for migraine (OR: 1.04; 95% CI: 0.02-0.06; P = 7.760E-5). Sensitivity analyses demonstrated the robustness of our findings.

Conclusion: Our study suggest that migraine may have potential causal relationships with AD and VaD. Migraine may be a risk factor for AD, and VaD may be a risk factor for migraine. Our study contributes to unraveling the comprehensive genetic associations between migraine and various types of dementia, and our findings will enhance the academic understanding of the comorbidity between migraine and dementia.

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来源期刊
BMC Medical Genomics
BMC Medical Genomics 医学-遗传学
CiteScore
3.90
自引率
0.00%
发文量
243
审稿时长
3.5 months
期刊介绍: BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
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