COVID-19 患者继发菌血症的时间和预测:回顾性队列研究

IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL
Aoi Yogo, Shungo Yamamoto MD, DTM&H, DrPH, Kentaro Tochitani
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引用次数: 0

摘要

背景:我们旨在通过确定继发性菌血症的发生时间以及验证和更新COVID-19患者菌血症的临床预测模型,帮助合理使用抗菌药物:我们对2020年1月1日至2021年9月30日期间在日本一家城市教学医院接受血液培养检测的所有确诊为COVID-19的住院患者进行了一项回顾性队列研究。主要结果指标是 COVID-19 患者的继发性菌血症:结果:在 507 名 COVID-19 住院患者中,169 人接受了血液培养检测。其中 11 人继发菌血症。大多数继发性菌血症发生在症状出现后的第 9 天或更晚。发病后第 9 天或更晚采集到的血培养阳性样本的几率为 22.4(95% CI 2.76-181.2,P 结论):症状发作和入院时间可能是临床决定对 COVID-19 住院患者进行血液培养的重要指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Timing and prediction of secondary bacteremia in patients with COVID-19: A retrospective cohort study

Timing and prediction of secondary bacteremia in patients with COVID-19: A retrospective cohort study

Background

We aimed to aid the appropriate use of antimicrobial agents by determining the timing of secondary bacteremia and validating and updating clinical prediction models for bacteremia in patients with COVID-19.

Methods

We performed a retrospective cohort study on all hospitalized patients diagnosed with COVID-19 who underwent blood culture tests from January 1, 2020, and September 30, 2021, at an urban teaching hospital in Japan. The primary outcome measure was secondary bacteremia in patients with COVID-19.

Results

Of the 507 patients hospitalized with COVID-19, 169 underwent blood culture tests. Eleven of them had secondary bacteremia. The majority of secondary bacteremia occurred on or later than the 9th day after symptom onset. Positive blood culture samples collected on day 9 or later after disease onset had an odds ratio of 22.4 (95% CI 2.76–181.2, p < 0.001) compared with those collected less than 9 days after onset. The area under the receiver operating characteristic curve of the modified Shapiro rule combined with blood culture collection on or after the 9th day from onset was 0.919 (95% CI, 0.843–0.995), and the net benefit was high according to the decision curve analysis.

Conclusions

The timings of symptom onset and hospital admission may be valuable indicators for making a clinical decision to perform blood cultures in patients hospitalized with COVID-19.

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来源期刊
Journal of General and Family Medicine
Journal of General and Family Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
自引率
6.20%
发文量
79
审稿时长
48 weeks
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