在抗血管内皮生长因子和 XELOX 治疗 pMMR 转移性结直肠癌的一线治疗中加入 PD-1 抑制剂：垫脚石、绊脚石和下一阶段。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-09-13 Epub Date: 2024-07-03 DOI:10.1016/j.medj.2024.06.006

Torhild Veen, Kjetil Søreide

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引用次数: 0

摘要

在Wang等人1的随机、双盲、多中心研究中，在抗血管内皮生长因子（HLX04；贝伐珠单抗的生物类似物）和化疗（XELOX）中加入serplulimab（一种PD-1抗体）被认为是可耐受的、安全的，并可改善无进展生存期。不过，即使不良事件具有可比性，包括生存期在内的肿瘤学终点仍需在下一项三期研究中得到确认。

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Adding first-line PD-1 inhibition to anti-VEGF and XELOX in pMMR metastatic colorectal cancer: Steppingstones, stumbling blocks, and next phase.

In the randomized, double-blind, multicenter study by Wang et al.,¹ the addition of serplulimab (a PD-1 antibody) to anti-VEGF (HLX04; a bevacizumab biosimilar) together with chemotherapy (XELOX) was deemed to be tolerable and safe and may improve progression-free survival. However, even if adverse events were comparable, oncological endpoints including survival need to be confirmed in the next phase 3 study.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.