David Bergman, Fahim Ebrahimi, Jiangwei Sun, Cecilia Norin, Kaziwe Mollazadegan, Jonas F Ludvigsson
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Patients with MC were matched (by age, sex, county and year of birth) with 68,753 controls from the general population and the occurrence of preceding inflammatory eye diseases (defined as diagnosis of episcleritis or iridocyclitis) in the two groups was compared. Multivariable adjusted odds ratios (aORs) were calculated using conditional logistic regression conditioned on the matching variables.</p><p><strong>Results: </strong>A majority of patients with MC were women (71.9%) and the median age at MC diagnosis was 63.3 years (interquartile range (IQR) = 50.7-72.6). Some 225 (1.6%) MC patients had an earlier record of inflammatory eye disease compared with 614 (0.9%) in controls. These figures corresponded to an aOR of 1.77 (95% CI = 1.52-2.07) for inflammatory eye diseases in patients with MC. Compared to siblings, the aOR for previous inflammatory eye diseases in MC was 1.52 (95% CI = 1.17-1.98) and patients treated with budesonide, as a proxy for clinically significant disease, had a somewhat higher aOR for previous inflammatory eye diseases.</p><p><strong>Conclusion: </strong>Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. Our findings highlight that these conditions may have shared causes and inflammatory pathways and are of clinical interest to gastroenterologists, ophthalmologists and general practitioners.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485298/pdf/","citationCount":"0","resultStr":"{\"title\":\"Inflammatory eye disease is a risk factor for future microscopic colitis: A nationwide population-based matched case control study.\",\"authors\":\"David Bergman, Fahim Ebrahimi, Jiangwei Sun, Cecilia Norin, Kaziwe Mollazadegan, Jonas F Ludvigsson\",\"doi\":\"10.1002/ueg2.12623\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Microscopic colitis (MC) is an inflammatory disorder of the colon. To date, the relationship between inflammatory eye diseases and MC is unclear.</p><p><strong>Objective: </strong>To assess whether inflammatory eye disease (iridocyclitis and episcleritis) is a risk factor for MC.</p><p><strong>Methods: </strong>We conducted a nationwide matched case control study in Sweden leveraging the ESPRESSO-study (a Swedish database containing data on all biopsies from the gastrointestinal tract from 1965 to 2017). In total, we identified 14,338 patients with biopsy-verified MC (diagnosed from 1981 to 2017). Patients with MC were matched (by age, sex, county and year of birth) with 68,753 controls from the general population and the occurrence of preceding inflammatory eye diseases (defined as diagnosis of episcleritis or iridocyclitis) in the two groups was compared. Multivariable adjusted odds ratios (aORs) were calculated using conditional logistic regression conditioned on the matching variables.</p><p><strong>Results: </strong>A majority of patients with MC were women (71.9%) and the median age at MC diagnosis was 63.3 years (interquartile range (IQR) = 50.7-72.6). Some 225 (1.6%) MC patients had an earlier record of inflammatory eye disease compared with 614 (0.9%) in controls. These figures corresponded to an aOR of 1.77 (95% CI = 1.52-2.07) for inflammatory eye diseases in patients with MC. Compared to siblings, the aOR for previous inflammatory eye diseases in MC was 1.52 (95% CI = 1.17-1.98) and patients treated with budesonide, as a proxy for clinically significant disease, had a somewhat higher aOR for previous inflammatory eye diseases.</p><p><strong>Conclusion: </strong>Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. 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引用次数: 0
摘要
背景:显微结肠炎(MC)是结肠的一种炎症性疾病。迄今为止,炎症性眼病与 MC 的关系尚不明确:评估炎症性眼病(虹膜睫状体炎和上睑下垂)是否是 MC 的危险因素:我们利用瑞典ESPRESSO研究(一个包含1965年至2017年期间所有胃肠道活检数据的瑞典数据库)在瑞典开展了一项全国范围的匹配病例对照研究。我们共发现了14338名经活检证实的MC患者(诊断时间为1981年至2017年)。我们将 MC 患者与 68,753 名普通人群中的对照组进行了配对(按年龄、性别、县和出生年份),并比较了两组患者之前发生炎症性眼病(定义为诊断为上睑巩膜炎或虹膜睫状体炎)的情况。使用条件逻辑回归法计算了以匹配变量为条件的多变量调整几率比(aORs):大多数 MC 患者为女性(71.9%),确诊 MC 的中位年龄为 63.3 岁(四分位距 (IQR) = 50.7-72.6)。约有 225 名(1.6%)MC 患者较早患有炎症性眼病,而对照组中仅有 614 名(0.9%)患者较早患有炎症性眼病。这些数字表明,MC 患者患炎症性眼病的 aOR 为 1.77(95% CI = 1.52-2.07)。与同胞兄弟相比,MC 患者曾患炎症性眼病的 aOR 为 1.52(95% CI = 1.17-1.98),而接受布地奈德治疗的患者(作为临床重大疾病的代表)曾患炎症性眼病的 aOR 略高:结论:炎症性眼病在随后被诊断为 MC 的患者中更为常见。我们的研究结果表明,这些疾病可能有共同的病因和炎症途径,这对消化科医生、眼科医生和全科医生都有临床意义。
Inflammatory eye disease is a risk factor for future microscopic colitis: A nationwide population-based matched case control study.
Background: Microscopic colitis (MC) is an inflammatory disorder of the colon. To date, the relationship between inflammatory eye diseases and MC is unclear.
Objective: To assess whether inflammatory eye disease (iridocyclitis and episcleritis) is a risk factor for MC.
Methods: We conducted a nationwide matched case control study in Sweden leveraging the ESPRESSO-study (a Swedish database containing data on all biopsies from the gastrointestinal tract from 1965 to 2017). In total, we identified 14,338 patients with biopsy-verified MC (diagnosed from 1981 to 2017). Patients with MC were matched (by age, sex, county and year of birth) with 68,753 controls from the general population and the occurrence of preceding inflammatory eye diseases (defined as diagnosis of episcleritis or iridocyclitis) in the two groups was compared. Multivariable adjusted odds ratios (aORs) were calculated using conditional logistic regression conditioned on the matching variables.
Results: A majority of patients with MC were women (71.9%) and the median age at MC diagnosis was 63.3 years (interquartile range (IQR) = 50.7-72.6). Some 225 (1.6%) MC patients had an earlier record of inflammatory eye disease compared with 614 (0.9%) in controls. These figures corresponded to an aOR of 1.77 (95% CI = 1.52-2.07) for inflammatory eye diseases in patients with MC. Compared to siblings, the aOR for previous inflammatory eye diseases in MC was 1.52 (95% CI = 1.17-1.98) and patients treated with budesonide, as a proxy for clinically significant disease, had a somewhat higher aOR for previous inflammatory eye diseases.
Conclusion: Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. Our findings highlight that these conditions may have shared causes and inflammatory pathways and are of clinical interest to gastroenterologists, ophthalmologists and general practitioners.
期刊介绍:
United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.