辐射研究 75 年来发生了什么变化?- 澳大利亚人对部分主题的看法。

IF 2.5 3区 医学 Q2 BIOLOGY
Olga A Martin, Pamela J Sykes, Martin Lavin, Elette Engels, Roger F Martin
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引用次数: 0

摘要

本期《辐射研究》白金特刊回顾了与这 75 年有关的几个科学主题。在选择科学主题时考虑了两个标准。其一是相关研究活动在辐射研究学会(RRS)年会和学会期刊出版物中的曝光率,从而反映出辐射研究学会会员的兴趣。第二个标准是注重澳大利亚辐射研究学会会员的贡献。第一个主题是放射生物学对放射肿瘤学的贡献,由已故的 Rod Withers 和他年轻的同事 Lester Peters 这两位杰出的澳大利亚放射肿瘤学家主讲。另外两个主题也与放射肿瘤学有关;旨在开发实验性放射治疗模式的临床前研究,即微光束放射治疗(MRT)和奥格射频放射治疗。与微束放射治疗相比,后者的历史悠久,尤其是在澳大利亚,因为墨尔本澳大利亚同步加速器的相关医疗光束线直到2011年才启用。另一个主题是DNA修复,鉴于分子生物学诞生于20世纪50年代,该主题的发展轨迹与75年的关注期平行。低剂量放射生物学主题也有类似的时间轴,主要是由核时代引发的,这也与放射保护剂主题有关,尽管放射保护剂在癌症放射治疗中也有长期的潜在用途。最后,有两个主题与生物模拟有关。一个是微核试验,强调了南澳大利亚阿德莱德的 Michael Fenech 的开创性贡献,另一个是 γ-H2AX 试验及其广泛的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What's Changed in 75 Years of RadRes? - An Australian Perspective on Selected Topics.

Several scientific themes are reviewed in the context of the 75-year period relevant to this special platinum issue of Radiation Research. Two criteria have been considered in selecting the scientific themes. One is the exposure of the associated research activity in the annual meetings of the Radiation Research Society (RRS) and in the publications of the Society's Journal, thus reflecting the interest of members of RRS. The second criteria is a focus on contributions from Australian members of RRS. The first theme is the contribution of radiobiology to radiation oncology, featuring two prominent Australian radiation oncologists, the late Rod Withers and his younger colleague, Lester Peters. Two other themes are also linked to radiation oncology; preclinical research aimed at developing experimental radiotherapy modalities, namely microbeam radiotherapy (MRT) and Auger endoradiotherapy. The latter has a long history, in contrast to MRT, especially in Australia, given that the associated medical beamline at the Australian Synchrotron in Melbourne only opened in 2011. Another theme is DNA repair, which has a trajectory parallel to the 75-year period of interest, given the birth of molecular biology in the 1950s. The low-dose radiobiology theme has a similar timeline, predominantly prompted by the nuclear era, which is also connected to the radioprotector theme, although radioprotectors also have a long-established potential utility in cancer radiotherapy. Finally, two themes are associated with biodosimetry. One is the micronucleus assay, highlighting the pioneering contribution from Michael Fenech in Adelaide, South Australia, and the other is the γ-H2AX assay and its widespread clinical applications.

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来源期刊
Radiation research
Radiation research 医学-核医学
CiteScore
5.10
自引率
8.80%
发文量
179
审稿时长
1 months
期刊介绍: Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.
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