牙周病原体与癌症发展

IF 17.5 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Periodontology 2000 Pub Date : 2024-10-01 Epub Date: 2024-07-04 DOI:10.1111/prd.12590

Yuxi Zhou, Joerg Meyle, Sabine Groeger

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引用次数: 0

摘要

越来越多的证据表明，牙周病与各种癌症的发生有重要关联。一些牙周病原体的致癌潜力已在体外和体内得到证实。本综述全面概述了不同牙周病原体在致癌过程中采用的各种机制。这些机制诱发慢性炎症、抑制宿主的免疫系统、激活细胞入侵和增殖、具有抗凋亡活性以及产生致癌物质。阐明这些机制可为开发预防肿瘤、治疗肿瘤和提高生存率的新方法提供新的见解。

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Periodontal pathogens and cancer development.

Increasing evidence suggests a significant association between periodontal disease and the occurrence of various cancers. The carcinogenic potential of several periodontal pathogens has been substantiated in vitro and in vivo. This review provides a comprehensive overview of the diverse mechanisms employed by different periodontal pathogens in the development of cancer. These mechanisms induce chronic inflammation, inhibit the host's immune system, activate cell invasion and proliferation, possess anti-apoptotic activity, and produce carcinogenic substances. Elucidating these mechanisms might provide new insights for developing novel approaches for tumor prevention, therapeutic purposes, and survival improvement.

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来源期刊

Periodontology 2000 医学-牙科与口腔外科

CiteScore

34.10

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.