评估结核分枝杆菌 PCR 在排除活动性结核病中的作用。

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2024-07-02 DOI:10.1016/j.ajic.2024.06.023

Inge Rogers, Michelle A Barron

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引用次数: 0

摘要

使用酸性快速杆菌（AFB）染色和结核分枝杆菌（Mtb）聚合酶链反应（PCR）的实验室算法经常被用来取消隔离预防措施。一项对 52 名经培养确诊为肺 Mtb 患者的回顾性病例审查显示，4 名患者的痰 AFB 涂片和 Mtb PCR 均为阴性。他们都有感染 Mtb 的重要危险因素，并且干扰素释放检测呈阳性。PCR 检测结果阴性并不能排除 Mtb 诊断。

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Evaluating the role of Mycobacterium tuberculosis PCR in ruling out active tuberculosis.

Laboratory algorithms using Acid-Fast Bacilli staining and Mycobacterium tuberculosis (Mtb) polymerase chain reaction (PCR) are often used to remove isolation precautions. A retrospective case review of 52 patients with culture-confirmed pulmonary Mtb revealed 4 subjects with negative sputum Acid-Fast Bacilli smears and negative Mtb PCRs. All had significant risk factors for Mtb and had a positive interferon-gamma release assay. A negative PCR test result does not exclude an Mtb diagnosis.

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)