基于高密度脂蛋白的疗法:抗击病毒和细菌感染的前景广阔。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Alankrita Rani , Julia T. Stadler , Gunther Marsche
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引用次数: 0

摘要

高密度脂蛋白(HDL)水平低和功能受损一直与感染及其严重后果的易感性增加有关。这归因于高密度脂蛋白在维持细胞脂质平衡方面的关键作用,而细胞脂质平衡对免疫细胞和结构细胞的正常运作至关重要。高密度脂蛋白是一种多功能微粒,在宿主抵御病原体的过程中发挥多种效应。它具有天然纳米颗粒的功能,能够封存和中和潜在的有害物质,如细菌脂多糖。高密度脂蛋白具有抗病毒活性,能阻止病毒进入宿主细胞或与宿主细胞融合,从而停止病毒的复制周期。了解高密度脂蛋白与免疫系统之间的复杂关系可为开发抗击传染病和改善患者预后的新疗法提供创新目标。本综述旨在强调高密度脂蛋白在影响细菌和病毒感染过程中的作用及其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HDL-based therapeutics: A promising frontier in combating viral and bacterial infections

Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been consistently associated with increased susceptibility to infection and its serious consequences. This has been attributed to the critical role of HDL in maintaining cellular lipid homeostasis, which is essential for the proper functioning of immune and structural cells. HDL, a multifunctional particle, exerts pleiotropic effects in host defense against pathogens. It functions as a natural nanoparticle, capable of sequestering and neutralizing potentially harmful substances like bacterial lipopolysaccharides. HDL possesses antiviral activity, preventing viruses from entering or fusing with host cells, thereby halting their replication cycle. Understanding the complex relationship between HDL and the immune system may reveal innovative targets for developing new treatments to combat infectious diseases and improve patient outcomes. This review aims to emphasize the role of HDL in influencing the course of bacterial and viral infections and its and its therapeutic potential.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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