{"title":"利用纳米技术操控细胞 Ca2+ 信号传导","authors":"Yaofeng Zhou, Zherui Zhang, Chen Zhou, Yuanhong Ma, Haoye Huang, Junqiu Liu, Dingcheng Zhu","doi":"10.1002/smsc.202400169","DOIUrl":null,"url":null,"abstract":"The manipulation of cytosolic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) plays a crucial role in the study of Ca<sup>2+</sup> signaling and the therapy of its affected diseases. Nanotechnology enables the development of nanotransducers for targeted, non-invasive, highly spatiotemporal, and on-demand [Ca<sup>2+</sup>]<sub>i</sub> regulation by responding to external energy fields to activate Ca<sup>2+</sup> channels, in situ deliver Ca<sup>2+</sup>, or release the payload of chemical modulators. As considerable strides have been made in Ca<sup>2+</sup> signaling-related fundamental research and applications in recent years, in this article, it is tried to present a thorough review of nanotransducer-based [Ca<sup>2+</sup>]<sub>i</sub> manipulation, from the working principle to specific applications. Focusing on the design rationale and constructions of nanotransducers, the interactions between nanotransducers and Ca<sup>2+</sup> channels are highlighted, as well as the downstream effectors of Ca<sup>2+</sup> signaling pathways, followed by their representative biomedical applications in disease treatment and neuromodulation. Moreover, despite the enormous progress made to date, nanotransducer-regulated Ca<sup>2+</sup> signaling still confronts obstacles, and several scientific issues urgently need to be resolved. Thus, to provide brief and valid instructions for the development of nanotransducers for the regulation of Ca<sup>2+</sup> signaling, proposals on how to improve the nanotransducer-based [Ca<sup>2+</sup>]<sub>i</sub> manipulation as well as future challenges and prospects are discussed.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"23 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanotechnology-Fortified Manipulation of Cell Ca2+ Signaling\",\"authors\":\"Yaofeng Zhou, Zherui Zhang, Chen Zhou, Yuanhong Ma, Haoye Huang, Junqiu Liu, Dingcheng Zhu\",\"doi\":\"10.1002/smsc.202400169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The manipulation of cytosolic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) plays a crucial role in the study of Ca<sup>2+</sup> signaling and the therapy of its affected diseases. Nanotechnology enables the development of nanotransducers for targeted, non-invasive, highly spatiotemporal, and on-demand [Ca<sup>2+</sup>]<sub>i</sub> regulation by responding to external energy fields to activate Ca<sup>2+</sup> channels, in situ deliver Ca<sup>2+</sup>, or release the payload of chemical modulators. As considerable strides have been made in Ca<sup>2+</sup> signaling-related fundamental research and applications in recent years, in this article, it is tried to present a thorough review of nanotransducer-based [Ca<sup>2+</sup>]<sub>i</sub> manipulation, from the working principle to specific applications. Focusing on the design rationale and constructions of nanotransducers, the interactions between nanotransducers and Ca<sup>2+</sup> channels are highlighted, as well as the downstream effectors of Ca<sup>2+</sup> signaling pathways, followed by their representative biomedical applications in disease treatment and neuromodulation. Moreover, despite the enormous progress made to date, nanotransducer-regulated Ca<sup>2+</sup> signaling still confronts obstacles, and several scientific issues urgently need to be resolved. Thus, to provide brief and valid instructions for the development of nanotransducers for the regulation of Ca<sup>2+</sup> signaling, proposals on how to improve the nanotransducer-based [Ca<sup>2+</sup>]<sub>i</sub> manipulation as well as future challenges and prospects are discussed.\",\"PeriodicalId\":29791,\"journal\":{\"name\":\"Small Science\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smsc.202400169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202400169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Nanotechnology-Fortified Manipulation of Cell Ca2+ Signaling
The manipulation of cytosolic Ca2+ concentration ([Ca2+]i) plays a crucial role in the study of Ca2+ signaling and the therapy of its affected diseases. Nanotechnology enables the development of nanotransducers for targeted, non-invasive, highly spatiotemporal, and on-demand [Ca2+]i regulation by responding to external energy fields to activate Ca2+ channels, in situ deliver Ca2+, or release the payload of chemical modulators. As considerable strides have been made in Ca2+ signaling-related fundamental research and applications in recent years, in this article, it is tried to present a thorough review of nanotransducer-based [Ca2+]i manipulation, from the working principle to specific applications. Focusing on the design rationale and constructions of nanotransducers, the interactions between nanotransducers and Ca2+ channels are highlighted, as well as the downstream effectors of Ca2+ signaling pathways, followed by their representative biomedical applications in disease treatment and neuromodulation. Moreover, despite the enormous progress made to date, nanotransducer-regulated Ca2+ signaling still confronts obstacles, and several scientific issues urgently need to be resolved. Thus, to provide brief and valid instructions for the development of nanotransducers for the regulation of Ca2+ signaling, proposals on how to improve the nanotransducer-based [Ca2+]i manipulation as well as future challenges and prospects are discussed.
期刊介绍:
Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.