一只患有慢性肝炎且肝组织中存在钩端螺旋体的狗患上肝T细胞淋巴瘤

IF 0.3 Q4 VETERINARY SCIENCES

Veterinary Record Case Reports Pub Date : 2024-07-02 DOI:10.1002/vrc2.926

Katerina Holenova, Chiara Giannasi, Elizabeth Alloway, Aaron Harper

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引用次数: 0

摘要

一只 7 岁的雌性阉割边境牧羊犬因肝酶升高并伴有轻微的非特异性临床症状而被转诊。随后的检查发现该犬患有慢性化脓性肝炎、铜蓄积以及肝组织中存在繁殖的钩端螺旋体。多西环素和 D-青霉胺治疗后，肝脏指标和临床症状有所改善。然而，在开始治疗 9 个月后，该犬再次就诊，表现为整体状况恶化、小肠腹泻和咳嗽。检查结果与肝大细胞淋巴瘤一致。该犬在确诊后不久即被安乐死，从肝脏提取的死后样本的组织病理学检查显示，组织中存在 CD3+、CD11d+ T 细胞淋巴瘤以及繁殖的钩端螺旋体。

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Hepatic T‐cell lymphoma in a dog with chronic hepatitis and presence of Leptospira spp. in hepatic tissue

A 7‐year‐old, female, neutered Border collie was referred for investigation of increased liver enzymes, accompanied by mild non‐specific clinical signs. Investigations subsequently revealed the presence of chronic pyogranulomatous hepatitis, copper accumulation and presence of multiplying Leptospira spp. in the liver tissue. Following treatment with doxycycline and D‐penicillamine, the liver parameters and clinical signs improved. However, 9 months after the treatment was initiated, the dog re‐presented for overall deterioration, small intestinal diarrhoea and cough. Investigations were consistent with a hepatic large cell lymphoma. The dog was euthanased shortly after diagnosis, and histopathology of the postmortem samples taken from the liver showed presence of CD3+, CD11d+ T‐cell lymphoma as well as multiplying Leptospira spp. in the tissue.

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来源期刊

Veterinary Record Case Reports Veterinary-Veterinary (all)

CiteScore

0.50

自引率

33.30%

发文量

266

期刊介绍： Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.