含有决明子甲醇提取物的新型聚乙烯吡咯烷酮纳米纤维的合成、表征和生物学评价

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Chou-Yi Husen, Uday Abdul-Reda Hussein, Amjed Qasim Mohammed, Eman Ramzy Muhammad, Kadhum Al-Majdi, Usama Kadem Radi, Ahmed Ali Ami, Anaheed Hussein Kareem, Irfan Ahmad, Saeb Jasim Al-Shuwaili, Ahmed Huseen Redhee
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引用次数: 0

摘要

本研究涉及沙特阿拉伯决明子甲醇提取物的制备以及含有沙特阿拉伯决明子甲醇提取物的聚乙烯吡咯烷酮(PVP)纳米纤维的生产。使用聚乙烯吡咯烷酮的原因是其生物活性及其物理和化学特性。利用傅立叶变换红外光谱(FTIR)、元素分析、扫描电子显微镜(SEM)图像、N2 吸附-解吸曲线、亲水性、抗压强度和抗折强度证实了新合成纳米纤维的结构和特性。还评估了生物活性,包括对皮肤癌细胞和骨癌细胞的抗癌特性,以及对革兰氏阳性和阴性菌株的抗菌活性。含有沙特阿拉伯决明子甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维的平均直径和比表面积分别为 87 nm 和 1 108 m2/g。与聚乙烯吡咯烷酮相比,纳米纤维具有较高的亲水性(合成纳米纤维的接触角为 21°,聚乙烯吡咯烷酮的接触角为 52°),与聚乙烯吡咯烷酮相比,纳米纤维具有较高的抗压强度(分别为 61.23 N/mm2 和 34.52 N/mm2),以及与聚乙烯吡咯烷酮相比具有较高的抗弯强度(分别为 16.1 N/mm2 和 11.4 N/mm2),这些是含有沙特阿拉伯决明子甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维的其他特点。在合成纳米纤维的生物活性方面,观察到了其独特的特性。在抗癌活性方面,对皮肤癌细胞和骨癌细胞的 IC50 值分别为 19.59 μg/mL 和 29.57 μg/mL。在抗菌活性方面,观察到的 MIC 值介于 4 至 128 mg/mL 之间。含有沙特阿拉伯决明子甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维的生物活性高于沙特阿拉伯决明子甲醇提取物。合成纳米纤维的高比表面积等多种因素可增强其生物特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, characterization, and biological evaluation of novel Polyvinylpyrrolidone nanofibers containing Cassia angustifolia Vahl methanolic extract
This study involved the preparation of the Saudi Arabian Cassia angustifolia Vahl methanolic extract and the production of polyvinylpyrrolidone (PVP) nanofibers that contained the Saudi Arabian C. angustifolia Vahl methanolic extract. The reason for using polyvinylpyrrolidone is its bioactivity and its physical and chemical properties. The structure and characterization of the newly synthesized nanofiber were confirmed using the Fourier-transform infrared (FTIR) spectrum, elemental analysis, scanning electron microscopy (SEM) image, N2 adsorption–desorption curve, hydrophilicity, compressive strength, and flexural strength. The biological activity, including anticancer properties against skin cancer cells and bone cancer cells and antibacterial activity against Gram-positive and Gram-negative strains, was assessed. The average diameter and the specific surface area of the synthesized polyvinylpyrrolidone nanofibers containing the Saudi Arabian Cassia angustifolia Vahl methanolic extract were 87 nm and 1,108 m2/g, respectively. High hydrophilicity compared to polyvinylpyrrolidone (contact angle of synthetic nanofibers was 21° and for polyvinylpyrrolidone was 52°), high compressive strength compared to polyvinylpyrrolidone (61.23 N/mm2 and 34.52 N/mm2, respectively), and high flexural strength compared to polyvinylpyrrolidone (16.1 N/mm2 and 11.4 N/mm2, respectively) were other characteristics of the synthesized polyvinylpyrrolidone nanofibers containing the Saudi Arabian Cassia angustifolia Vahl methanolic extract. In the biological activities of the synthesized nanofiber, unique properties were observed. Regarding the anticancer activity, the IC50 values against skin cancer cells and bone cancer cells were observed to be 19.59 μg/mL and 29.57 μg/mL, respectively. For the antimicrobial activity, the MIC value between 4 and 128 mg/mL was observed. The biological activities of the synthesized polyvinylpyrrolidone nanofibers containing the Saudi Arabian Cassia angustifolia Vahl methanolic extract were higher than those of the Saudi Arabian Cassia angustifolia Vahl methanolic extract. The biological properties can be enhanced by various factors, including the high specific surface area of the synthesized nanofiber.
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来源期刊
Frontiers in Materials
Frontiers in Materials Materials Science-Materials Science (miscellaneous)
CiteScore
4.80
自引率
6.20%
发文量
749
审稿时长
12 weeks
期刊介绍: Frontiers in Materials is a high visibility journal publishing rigorously peer-reviewed research across the entire breadth of materials science and engineering. This interdisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers across academia and industry, and the public worldwide. Founded upon a research community driven approach, this Journal provides a balanced and comprehensive offering of Specialty Sections, each of which has a dedicated Editorial Board of leading experts in the respective field.
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