Zhuochao Zheng, Jun Li*, Yang Jin and Tianliang Zhang,
{"title":"利用晶体自桥接机制设计的新型环保球形聚结工艺:肌醇案例研究","authors":"Zhuochao Zheng, Jun Li*, Yang Jin and Tianliang Zhang, ","doi":"10.1021/acs.cgd.4c00489","DOIUrl":null,"url":null,"abstract":"<p >Environmental-friendly spherical crystallization technology has always been the focus in the field of crystallization. In this work, a novel crystal self-bridging (CSB) mechanism is proposed. In the absence of additives and organic solvents, preliminary agglomeration is generated through the adhesion force between crystals, and stable agglomeration is formed by the solid-bridge generated by crystal growth. The mechanism was explained from the perspective of the adhesion free energy. <i>Myo</i>-inositol (MI) was selected as the research object, and then a spherical agglomeration process was developed based on the CSB mechanism. Based on detailed experiments, we found that the seed size should be smaller than 100 μm (150 mesh). In addition, the optimal supersaturation ratio and suspension density should be 1.25 and 80 kg/m<sup>3</sup>, respectively. A fluidized bed crystallizer was used to enhance the crystallization process. Strategies of particle size control were proposed, and prediction equations for particle size were provided. The obtained spherical MI was compared with powdered and flaky MI, and then it was demonstrated that the spherical MI was excellent in terms of morphology, particle size distribution, flowability indicators, anticaking performance, and dissolution rate. The spherical particles of choline tartrate, niacinamide, and vitamin B1 were successfully prepared according to a CSB mechanism, so the universality of this mechanism was demonstrated. The results of this work provide effective guidance for improving the particle size and powder properties of MI and contribute to the promotion of the CSB mechanism to other systems.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel Environment-Friendly Spherical Agglomeration Process Designed by Crystal Self-Bridging Mechanism: A Case Study of Myo-Inositol\",\"authors\":\"Zhuochao Zheng, Jun Li*, Yang Jin and Tianliang Zhang, \",\"doi\":\"10.1021/acs.cgd.4c00489\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Environmental-friendly spherical crystallization technology has always been the focus in the field of crystallization. In this work, a novel crystal self-bridging (CSB) mechanism is proposed. In the absence of additives and organic solvents, preliminary agglomeration is generated through the adhesion force between crystals, and stable agglomeration is formed by the solid-bridge generated by crystal growth. The mechanism was explained from the perspective of the adhesion free energy. <i>Myo</i>-inositol (MI) was selected as the research object, and then a spherical agglomeration process was developed based on the CSB mechanism. Based on detailed experiments, we found that the seed size should be smaller than 100 μm (150 mesh). In addition, the optimal supersaturation ratio and suspension density should be 1.25 and 80 kg/m<sup>3</sup>, respectively. A fluidized bed crystallizer was used to enhance the crystallization process. Strategies of particle size control were proposed, and prediction equations for particle size were provided. The obtained spherical MI was compared with powdered and flaky MI, and then it was demonstrated that the spherical MI was excellent in terms of morphology, particle size distribution, flowability indicators, anticaking performance, and dissolution rate. The spherical particles of choline tartrate, niacinamide, and vitamin B1 were successfully prepared according to a CSB mechanism, so the universality of this mechanism was demonstrated. The results of this work provide effective guidance for improving the particle size and powder properties of MI and contribute to the promotion of the CSB mechanism to other systems.</p>\",\"PeriodicalId\":34,\"journal\":{\"name\":\"Crystal Growth & Design\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Crystal Growth & Design\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.cgd.4c00489\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystal Growth & Design","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.cgd.4c00489","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
环保型球形结晶技术一直是结晶领域的焦点。本研究提出了一种新型晶体自桥接(CSB)机制。在没有添加剂和有机溶剂的情况下,晶体间的粘附力产生初步团聚,晶体生长产生的固桥形成稳定团聚。从粘附自由能的角度解释了这一机制。我们选择肌醇(MI)作为研究对象,然后根据 CSB 机制开发了球形团聚过程。根据详细实验,我们发现种子尺寸应小于 100 μm(150 目)。此外,最佳过饱和比和悬浮密度应分别为 1.25 和 80 kg/m3。使用流化床结晶器来强化结晶过程。提出了粒度控制策略,并提供了粒度预测方程。将获得的球形 MI 与粉状和片状 MI 进行比较,结果表明球形 MI 在形态、粒度分布、流动性指标、抗结块性能和溶出率等方面均表现优异。根据 CSB 机制成功制备了酒石酸胆碱、烟酰胺和维生素 B1 的球形颗粒,证明了该机制的普遍性。这项工作的结果为改善 MI 的粒度和粉末性能提供了有效的指导,并有助于将 CSB 机制推广到其他体系。
Novel Environment-Friendly Spherical Agglomeration Process Designed by Crystal Self-Bridging Mechanism: A Case Study of Myo-Inositol
Environmental-friendly spherical crystallization technology has always been the focus in the field of crystallization. In this work, a novel crystal self-bridging (CSB) mechanism is proposed. In the absence of additives and organic solvents, preliminary agglomeration is generated through the adhesion force between crystals, and stable agglomeration is formed by the solid-bridge generated by crystal growth. The mechanism was explained from the perspective of the adhesion free energy. Myo-inositol (MI) was selected as the research object, and then a spherical agglomeration process was developed based on the CSB mechanism. Based on detailed experiments, we found that the seed size should be smaller than 100 μm (150 mesh). In addition, the optimal supersaturation ratio and suspension density should be 1.25 and 80 kg/m3, respectively. A fluidized bed crystallizer was used to enhance the crystallization process. Strategies of particle size control were proposed, and prediction equations for particle size were provided. The obtained spherical MI was compared with powdered and flaky MI, and then it was demonstrated that the spherical MI was excellent in terms of morphology, particle size distribution, flowability indicators, anticaking performance, and dissolution rate. The spherical particles of choline tartrate, niacinamide, and vitamin B1 were successfully prepared according to a CSB mechanism, so the universality of this mechanism was demonstrated. The results of this work provide effective guidance for improving the particle size and powder properties of MI and contribute to the promotion of the CSB mechanism to other systems.
期刊介绍:
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.