通过硼酸酯化学交联的 pH 值响应型可降解电纺纳米纤维用于智能伤口敷料

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sofia Nieves Casillas-Popova, Nishadi Dilkushi Lokuge, Brandon Andrade-Gagnon, Farhan Rahman Chowdhury, Cameron D. Skinner, Brandon L. Findlay, Jung Kwon Oh
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引用次数: 0

摘要

慢性伤口治疗领域的最新进展主要集中在开发基于纳米结构材料,特别是生物相容性聚乙烯醇(PVA)电纺纳米纤维的尖端伤口敷料的有效策略上。然而,PVA 纳米纤维需要进行化学交联,以确保其在水环境中的尺寸稳定性及其封装生物活性分子的能力。尽管有多种基于氨基甲酸酯、酯和缩醛键的化学交联模式,但仍存在一些局限性,包括不可降解性、不可控释放和细胞毒性。在此,我们报告了一种稳健的方法,通过 PVA 羟基与苯基二硼酸交联剂的硼酸基团的偶联反应,制造出 pH 值可降解的电子纺丝 PVA 纳米纤维,并与动态硼酸酯 (BE) 链接交联。我们的综合分析表明,硼酸与羟基的摩尔比对于制造定义明确的 BE 交联纤维毡非常重要,这种纤维毡不仅具有尺寸稳定性,还能在水溶液中保持均匀的纤维形态。这些纳米纤维可在模拟伤口环境的酸性和碱性条件下降解,从而控制/增强封装抗菌药物分子的释放。更重要的是,药物负载的硼酸酯交联纤维对革兰氏阳性菌和革兰氏阴性菌都显示出卓越的抗菌活性,这表明我们探索动态硼酸酯化学的方法适用于开发可控/增强药物释放的智能伤口敷料。本文受版权保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need to be chemically crosslinked to ensure their dimensional stability in aqueous environment and their capability to encapsulate bioactive molecules. Herein, a robust approach for the fabrication of pH-degradable e-spun PVA nanofibers crosslinked with dynamic boronic ester (BE) linkages through a coupling reaction of PVA hydroxyl groups with the boronic acid groups of a phenyl diboronic acid crosslinker is reported. This comprehensive analysis reveals the importance of the mole ratio of boronic acid to hydroxyl group for the fabrication of well-defined BE-crosslinked fibrous mats with not only dimensional stability but also the ability to retain uniform fibrous form in aqueous solutions. These nanofibers degrade in both acidic and basic conditions that mimic wound environments, leading to controlled/enhanced release of encapsulated antimicrobial drug molecules. More importantly, drug-loaded BE-crosslinked fibers show excellent antimicrobial activities against both Gram-positive and Gram-negative bacteria, suggesting that this approach of exploring dynamic BE chemistry is amenable to the development of smart wound dressings with controlled/enhanced drug release.

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来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
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