带有后向分岔和霍普夫分岔的川崎病血管内皮细胞损伤模型的全局动力学研究

IF 0.9 4区 数学 Q3 MATHEMATICS, APPLIED
Ke Guo, Wan-biao Ma
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引用次数: 0

摘要

川崎病(KD)是一种急性、发热性、全身性血管炎,主要影响五岁以下儿童。本文提出并研究了一类描述 KD 病变区血管内皮细胞损伤的五维常微分方程模型。该模型呈现前/后分叉。进一步,我们得到了无血管损伤平衡的全局渐近稳定性的两类充分条件,它们可同时适用于前向和后向分叉情况。此外,还研究了血管损伤平衡的局部和全局渐近稳定性以及霍普夫分岔的存在。研究还表明,如果基本繁殖数 R0 > 1,模型是永久性的,并给出了模型解的终极下限的一些明确解析表达式。我们的结果表明,KD 病变区血管损伤的控制不仅与基本繁殖数 R0 有关,还与血管内皮生长因子促进的正常血管内皮细胞的生长速度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global Dynamics of a Kawasaki Disease Vascular Endothelial Cell Injury Model with Backward Bifurcation and Hopf Bifurcation

Kawasaki disease (KD) is an acute, febrile, systemic vasculitis that mainly affects children under five years of age. In this paper, we propose and study a class of 5-dimensional ordinary differential equation model describing the vascular endothelial cell injury in the lesion area of KD. This model exhibits forward/backward bifurcation. It is shown that the vascular injury-free equilibrium is locally asymptotically stable if the basic reproduction number R0 < 1. Further, we obtain two types of suffcient conditions for the global asymptotic stability of the vascular injury-free equilibrium, which can be applied to both the forward and backward bifurcation cases. In addition, the local and global asymptotic stability of the vascular injury equilibria and the presence of Hopf bifurcation are studied. It is also shown that the model is permanent if the basic reproduction number R0 > 1, and some explicit analytic expressions of ultimate lower bounds of the solutions of the model are given. Our results suggest that the control of vascular injury in the lesion area of KD is not only correlated with the basic reproduction number R0, but also with the growth rate of normal vascular endothelial cells promoted by the vascular endothelial growth factor.

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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
70
审稿时长
3.0 months
期刊介绍: Acta Mathematicae Applicatae Sinica (English Series) is a quarterly journal established by the Chinese Mathematical Society. The journal publishes high quality research papers from all branches of applied mathematics, and particularly welcomes those from partial differential equations, computational mathematics, applied probability, mathematical finance, statistics, dynamical systems, optimization and management science.
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