阿昔洛韦与淀粉和羧甲基纤维素固体分散体的制备与研究

IF 1.6 4区化学 Q4 POLYMER SCIENCE

Polymer Science, Series C Pub Date : 2024-07-03 DOI:10.1134/s1811238224600101

T. V. Kryuk, T. N. Popyrina, N. A. Romanenko, P. L. Ivanov, N. B. Svishcheva, T. A. Akopova, M. A. Khavpachev

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引用次数: 0

摘要

摘要--通过机械化学方法制备了基于阿昔洛韦和多糖（淀粉和羧甲基纤维素钠）的固体分散体。在球磨机、挤压机和脉冲机械作用池中对药物和聚合物进行机械共处理后，阿昔洛韦发生了非晶化，随后均匀地分布在聚合物基质中。一组红外光谱、紫外光谱、DSC 和 X 射线衍射分析数据显示，多糖基质与药物之间存在分子间相互作用。所获得的材料可被视为具有进一步研究潜力的系统，作为阿昔洛韦的固体制剂，可提高其生物利用率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preparation and Study of Solid Dispersions of Acyclovir with Starch and Carboxymethylcellulose

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Preparation and Study of Solid Dispersions of Acyclovir with Starch and Carboxymethylcellulose

Abstract—

Solid dispersions based on acyclovir and polysaccharides (starch and sodium carboxymethylcellulose) have been prepared by means of mechanochemistry. Mechanical co-processing of the drug and the polymers in a ball mill, an extruder, and a pulse mechanical action cell has led to amorphization of acyclovir, followed by its uniform distribution in the polymer matrix. A set of the IR and UV spectroscopy, DSC, and X-ray diffraction analysis data has revealed the presence of intermolecular interactions between the polysaccharide matrix and the drug. The obtained materials can be considered as potential system for further investigation as solid formulations of acyclovir with improved bioavailability.

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来源期刊

Polymer Science, Series C 工程技术-高分子科学

CiteScore

3.00

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： Polymer Science, Series C (Selected Topics) is a journal published in collaboration with the Russian Academy of Sciences. Series C (Selected Topics) includes experimental and theoretical papers and reviews on the selected actual topics of macromolecular science chosen by the editorial board (1 issue a year). Submission is possible by invitation only. All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed