用于在液相和气相中特异性检测沙林毒气模拟物氯磷酸二乙酯的高选择性色荧光探针

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Tuhina Sultana, Manas Mahato, Sabbir Ahamed, Najmin Tohora, Jyoti Chourasia, Shreya Ali and Sudhir Kumar Das
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引用次数: 0

摘要

在各种以有机磷为基础的化学战剂中,神经毒剂对国防和公共安全构成严重威胁。其中,沙林毒气是最近在各种恐怖活动中使用的一种严重毒气。目前,用于检测它们的色氟探针的开发仍处于起步阶段。针对这一方向,本文介绍了一种高选择性和特异性的色氟探针--(E)-3-(((4-(苯并[d]恶唑-2-基)苯基)亚氨基)甲基)-2-甲氧基-2H-苯并吡喃-4-醇(TSB),该探针包含色酮和苯并恶唑分子,可分别在气相和溶液相中识别沙林毒气的代用品--氯磷酸二乙酯(DCP)。在纯二甲基亚砜和 50% v/v 水-二甲基亚砜混合物中的 TSB 溶液中加入二氯丙醇后,可观察到从淡黄色变为无色。此外,在 365 纳米紫外灯的照射下,还出现了从无荧光到强烈蓝紫色光致发光增强的转变。研究发现,这些光学信号是由于磷酸化 TSB-DCP 产物的产生,抑制了参与 TSB 的分子内电荷转移(ICT)和激发态分子内质子转移(ESIPT)机制。所开发的传感器证明,即使在存在其他各种具有挑战性的受邀分析物的情况下,也能检测出 DCP,其识别和定量限在 µM 范围内。此外,为了实现现场检测 DCP 并研究开发的探针的实用性,我们还演示了纸条式检测试剂盒的使用方法和 "浸签 "法,特别是对添加剂的土壤样品进行了实际样品分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A highly selective chromo-fluorogenic probe for specific detection of sarin gas simulant diethylchlorophosphate in liquid and vapor phases†

A highly selective chromo-fluorogenic probe for specific detection of sarin gas simulant diethylchlorophosphate in liquid and vapor phases†

Among the various organophosphorus-based chemical warfare agents, nerve agents pose severe threats to national defense and public safety. Among them, sarin gas is a severe one that has been employed in various terrorist activities recently. The development of chromo-fluorogenic probes for their detection is still in its infancy. Aiming in this direction, the present article introduces a highly selective and specific chromo-fluorogenic probe, (E)-3-(((4-(benzo[d]oxazol-2-yl)phenyl)imino)methyl)-2-methoxy-2H-chromen-4-ol (TSB) embracing chromone and benzoxazole moieties, for the recognition of diethyl chlorophosphate (DCP), a sarin gas surrogate, in both gaseous and solution phases, respectively. Upon adding DCP to the TSB solution in pure DMSO and 50% v/v water–DMSO mixture, there is an observable change from very pale yellow to colorless. Additionally, there is a transition from no fluorescence to intense blue-violet photoluminescence enhancement under exposure to a 365 nm UV lamp. These optical signals are found to be due to the development of phosphorylated TSB–DCP products, inhibiting intramolecular charge transfer (ICT) and the excited state intramolecular proton transfer (ESIPT) mechanism involved in TSB. The developed sensor demonstrated the ability to detect DCP even in the presence of various other challenging guest analytes, achieving a recognition and quantification limit in the μM range. Furthermore, to achieve on-site detection of DCP and investigate the practical utility of the developed probe, we have demonstrated the use of a paper strip-based test kit, the “dip-stick” method, and, notably, conducted real sample analysis on spiked soil samples.

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