合成天然花翠素的 N-杂环类似物--有望成为抗肿瘤药物

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-06-21 DOI:10.1007/s11172-024-4259-x

R. A. Tuktarova, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov

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引用次数: 0

摘要

研究人员合成了各种炔苷元的前体--毛花苷的一系列 N-杂环类似物，并对其生物活性进行了研究。研究发现，N-甲基吡唑/咪唑部分与疏水性烷二烯基链之间的连接基团影响了这些化合物诱导细胞凋亡和导致细胞周期停滞的能力。化合物 3b 的细胞毒活性最高。

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Synthesis of N-heterocyclic analogs of natural muricadienin — promising antitumor agents

A series of N-heterocyclic analogs of muricadienin, a precursor of various acetogenins, were synthesized, and their biological activity was studied. It was revealed that the linking group between the N-methylpyrazole/imidazole part and the hydrophobic alkadienyl chain affects the ability of these compounds to induce apoptosis and cause cell cycle arrest. Compound 3b showed the highest cytotoxic activity.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.