评估银-氧化石墨烯纳米复合材料对大肠杆菌和胶质母细胞瘤癌细胞的细胞毒性

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Marjan Moghayedi, Elaheh K. Goharshadi, Kiarash Ghazvini, Laleh Ranjbaran
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引用次数: 0

摘要

在这项研究中,我们考察了 Ag-氧化石墨烯(GO)纳米复合材料对革兰氏阴性菌大肠杆菌和胶质母细胞瘤癌细胞(U87MG)的毒性。我们的研究结果表明,Ag-GO 具有杀菌特性,最低抑菌浓度 (MIC) 和最低杀菌浓度 (MBC) 均为 160 µg/mL。Ag-GO的抗菌效果取决于接触时间和浓度,因此有可能被整合到用于抗微生物感染的材料中。Ag-GO的杀菌效果可归因于银离子的释放和GO片材锋利边缘造成的物理损伤。此外,我们的研究表明,Ag-GO 对 U87MG 细胞具有抗癌活性,其 IC50 值为 270 µg/mL。Ag-GO 的抗癌活性机制可能涉及细胞膜破坏和细胞凋亡诱导。这些发现表明,Ag-氧化石墨烯纳米复合材料具有广阔的医学和生物学应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Assessment of the cytotoxicity of silver-graphene oxide nanocomposites on Escherichia coli and glioblastoma cancer cells

Assessment of the cytotoxicity of silver-graphene oxide nanocomposites on Escherichia coli and glioblastoma cancer cells

In this research, we examined the toxicity of Ag-graphene oxide (GO) nanocomposites against both the Gram-negative bacterium Escherichia coli and Glioblastoma cancer cells (U87MG). Our findings reveal that Ag-GO possesses bactericidal properties, with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 160 µg/mL. The antibacterial efficacy of Ag-GO is contingent on contact time and concentration, making it a potential candidate for integration into materials designed to combat microbial infections. The bactericidal effect of Ag-GO can be attributed to the release of silver ions and the physical damage inflicted by the sharp edges of GO sheets. Furthermore, our study demonstrates that Ag-GO exhibits anticancer activity against U87MG cells, with an IC50 value of 270 µg/mL. The mechanism underlying the anticancer activity of Ag-GO likely involves cell membrane disruption and apoptosis induction. These findings signify the promising medical and biological applications of Ag-graphene oxide nanocomposites.

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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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