使用 DREAM 评估污水处理厂中药物和个人护理产品存在的相对风险

IF 6.1 2区 环境科学与生态学 Q2 ENGINEERING, ENVIRONMENTAL
Daniela M. Pampanin, Daniel Schlenk, Matteo Vitale, Pierre Liboureau, Magne O. Sydnes
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引用次数: 0

摘要

对与药品和个人护理产品(PPCPs)相关的环境风险的关注促使研究人员寻求评估和监测水生环境中这些污染物的方法。确定和验证能够评估与 PPCPs 相关的生态问题和风险的风险评估工具至关重要。在此,我们验证了与剂量相关的风险和影响评估模型的适用性,该模型可估算预测的环境浓度,并可与已确定的预测无影响浓度进行比较,同时还结合了对整个污水毒性的体外分析,以确定 PPCP 危害的特征。在进水和出水样本中测量了挪威使用最多的多氯联苯和多氯联苯的浓度,并将其用于命运模型的参数化。去除率与具体物质的类别或浓度无关,在 12% 到 100% 之间。利用排放废水中检测到的 PPCPs 来评估对废水风险的个别影响,结果发现目标 30 种 PPCPs 没有风险。生物测定(使用鱼肝细胞、PLHC-1)通过细胞活力、活性氧的产生以及乙氧苏木素-O-脱乙基酶(EROD)的活性来评估废水的总体毒性。本研究可使监管机构在监测研究中使用基于风险的策略而非去除标准,并证实了在制定环境法规时考虑 PPCP 污染的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Use of DREAM to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

Use of DREAM to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

Concerns related to environmental risks associated with pharmaceuticals and personal care products (PPCPs) have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic environment. Identifying and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPCPs is critical. Herein, the suitability of a dose-related risk and effect assessment model, which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined, in combination with in vitro analyses of the whole effluent toxicity, was verified for the characterization of a PPCP hazard. Concentrations of the most utilized PPCPs in Norway were measured in influent and effluent samples and used to parameterize the fate model.

Greater than 90% removal was attained for 12 out of 22 detected PPCPs. Removal was not dependent on the class or the concentration of the specific substance and varied between 12% and 100%. The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent, and no risk was identified for the targeted 30 PPCP. The simulations provided valuable information regarding the discharge plume distribution over time, which can aid planning of future environmental monitoring investigations.

Bioassays (using fish liver cells, PLHC-1) were used for assessing overall effluent toxicity, through cell viability, production of reactive oxygen species, and ethoxyresorufin-O-deethylase (EROD) activities.

The present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPCP contamination into consideration when establishing environmental regulations.

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来源期刊
Frontiers of Environmental Science & Engineering
Frontiers of Environmental Science & Engineering ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES
CiteScore
10.90
自引率
12.50%
发文量
988
审稿时长
6.1 months
期刊介绍: Frontiers of Environmental Science & Engineering (FESE) is an international journal for researchers interested in a wide range of environmental disciplines. The journal''s aim is to advance and disseminate knowledge in all main branches of environmental science & engineering. The journal emphasizes papers in developing fields, as well as papers showing the interaction between environmental disciplines and other disciplines. FESE is a bi-monthly journal. Its peer-reviewed contents consist of a broad blend of reviews, research papers, policy analyses, short communications, and opinions. Nonscheduled “special issue” and "hot topic", including a review article followed by a couple of related research articles, are organized to publish novel contributions and breaking results on all aspects of environmental field.
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