中国国家队列中与个人和共同暴露于 PM2.5 成分相关的认知障碍

IF 6.1 2区 环境科学与生态学 Q2 ENGINEERING, ENVIRONMENTAL
Boning Deng, Yachen Li, Lifeng Zhu, Yuwei Zhou, Aonan Sun, Jingjing Zhang, Yixiang Wang, Yuxi Tan, Jiajun Shen, Yalin Zhang, Zan Ding, Yunquan Zhang
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引用次数: 0

摘要

在中国,将认知功能下降与细颗粒物(PM2.5)暴露联系起来的全国性纵向证据仍然很少。通过在中国健康与退休纵向研究的基础上构建动态队列,我们旨在评估中国中老年人PM2.5成分与认知功能的个体和联合关联。我们采用了线性混合效应模型和基于量纲的 g 计算方法来研究长期暴露于 PM2.5 成分与认知功能之间的个体和联合关系。在 13,507 名受访者中,我们评估了 38,950 份认知功能测试的随访记录。与暴露量四分位数间距(IQR)增加相关的全球认知分数下降情况是:硝酸盐为-1.477(95% CI:-1.722,-1.232),其次是铵:-1.331(-1.529,-1.133),硫酸盐:-1.033(-1.184,-0.883),有机物:-0.988(-1.144,-0.832),黑碳:-0.822(-0.946,-0.699)。PM2.5中这些成分的IQR值每增加1,全球认知分数就会下降-1.353(-1.659,-1.048)。女性、年轻人和受过良好教育的人更容易受到与个人和共同暴露于PM2.5成分有关的认知障碍的影响。这项研究表明,中国中老年人在晚年暴露于PM2.5成分与认知能力下降有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cognitive impairment associated with individual and joint exposure to PM2.5 constituents in a Chinese national cohort

Cognitive impairment associated with individual and joint exposure to PM2.5 constituents in a Chinese national cohort

Nationwide longitudinal evidence linking cognitive decline with exposure to fine particulate matter (PM2.5) constituents remains scarce in China. By constructing a dynamic cohort based on the China Health and Retirement Longitudinal Study, we aimed to assess individual and joint associations of PM2.5 constituents with cognitive function among middle-aged and older adults in China. Linear mixed-effects models incorporated with quantile-based g-computation were applied to investigate individual and joint associations of long-term exposures to PM2.5 constituents with cognitive function. Among 13,507 respondents, we evaluated 38,950 follow-up records of cognitive function tests. Declines in global cognitive score associated with an interquartile range (IQR) increase in exposure were −1.477 (95% CI: −1.722, −1.232) for nitrate, followed by −1.331 (−1.529, −1.133) for ammonium, −1.033 (−1.184, −0.883) for sulfate, −0.988 (−1.144, −0.832) for organic matter and −0.822 (−0.946, −0.699) for black carbon. An IQR-equivalent increase in joint exposure to these PM2.5 constituents was associated with a decline of −1.353 (−1.659, −1.048) in global cognitive score. Female, younger, and well-educated individuals were at greater vulnerability to cognitive impairment related to individual and joint exposure to PM2.5 constituents. This study suggested that later-life exposures to PM2.5 constituents were associated with cognitive decline in middle-aged and older adults in China.

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来源期刊
Frontiers of Environmental Science & Engineering
Frontiers of Environmental Science & Engineering ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES
CiteScore
10.90
自引率
12.50%
发文量
988
审稿时长
6.1 months
期刊介绍: Frontiers of Environmental Science & Engineering (FESE) is an international journal for researchers interested in a wide range of environmental disciplines. The journal''s aim is to advance and disseminate knowledge in all main branches of environmental science & engineering. The journal emphasizes papers in developing fields, as well as papers showing the interaction between environmental disciplines and other disciplines. FESE is a bi-monthly journal. Its peer-reviewed contents consist of a broad blend of reviews, research papers, policy analyses, short communications, and opinions. Nonscheduled “special issue” and "hot topic", including a review article followed by a couple of related research articles, are organized to publish novel contributions and breaking results on all aspects of environmental field.
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