对于肝脏清除的药物，稳态时肝脏到血液的 KPUU 始终等于 FH，这暴露了目前扩展清除概念方程的不足之处

{"title":"对于肝脏清除的药物，稳态时肝脏到血液的 KPUU 始终等于 FH，这暴露了目前扩展清除概念方程的不足之处","authors":"Leslie Z. Benet, Jasleen K. Sodhi","doi":"10.1016/j.dmpk.2023.100919","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"17 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation\",\"authors\":\"Leslie Z. Benet, Jasleen K. Sodhi\",\"doi\":\"10.1016/j.dmpk.2023.100919\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":11298,\"journal\":{\"name\":\"Drug Metabolism and Pharmacokinetics\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Metabolism and Pharmacokinetics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.dmpk.2023.100919\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Metabolism and Pharmacokinetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.dmpk.2023.100919","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}