基线时的就业、教育或培训状况（NEET）可预测初发精神病的高阈值症状缓解：一项队列研究

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2024-06-21 DOI:10.1111/eip.13586

Jessica Buckle, Gail Kavanagh, Aries Connolly, Sophie Arora, Emily Forshall, Titus Murphy, Marco Pereira, Richard Whale

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引用次数: 0

摘要

目的首次精神病发作（FEP）后的临床研究日益暴露出确定预测结果变量的复杂性。我们的目的是探讨首次精神病发作时的 NEET 状态（未接受教育、就业或培训）在预测接受精神病早期干预服务治疗 3 年后的高阈值临床缓解（无阳性症状且停用抗精神病药物 6 个月）方面的效用。结果有 172 名患者（49%）的基线 NEET 状态被确定，且与未治疗精神病的平均持续时间显著相关（p = .035）。只有 64 名患者（21%）在 3 年内达到了规定的缓解标准。多变量逻辑回归分析显示，基线NEET状态是唯一与缓解状态显著相关的变量（p = .001）。

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Employment, education or training status (NEET) at baseline predicts high-threshold symptomatic remission in first episode psychosis: A cohort study

Aim

Clinical studies following a first episode of psychosis (FEP) have increasingly exposed the complexity of identifying predictive outcome variables. We aimed to explore the utility of NEET status (not in education, employment or training) at FEP onset in predicting high threshold clinical remission (absence of positive symptoms and off antipsychotic medication for 6 months) at 3 years following treatment with an early intervention for psychosis service.

Methods

We studied an established retrospective naturalistic cohort of 354 patients with FEP (the S1P cohort).

Results

Baseline NEET status was identified in 172 patients (49%) and was significantly associated with mean duration of untreated psychosis (p = .035). Only 64 (21%) achieved defined remission criteria by 3 years. Multivariate logistic regression analysis revealed baseline NEET status as the only variable significantly associated with remission status (p < .001).

Conclusion

NEET may represent an important predictive variable of symptomatic outcomes which requires prospective evaluation.

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.