{"title":"过敏性支气管肺曲霉菌病,同时分离出三种不同的曲霉菌。","authors":"Yosuke Sasahara, Kentaro Akata, Kei Yamasaki, Takeshi Orihashi, Kazuhiro Yatera","doi":"10.1002/rcr2.1423","DOIUrl":null,"url":null,"abstract":"<p><p>Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease induced by exaggerated immune responses to <i>Aspergillus</i> species. Although ABPA has a high recurrence (48%), its instances with sequential isolation of distinct <i>Aspergillus</i> species are sporadic. Only one case report has documented the metachronous isolation of <i>Aspergillus fumigatus</i> and <i>Aspergillus flavus</i>. However, no reported cases of metachronous isolation involving three distinct <i>Aspergillus</i> species exist. Herein, we report a novel case of a 47-year-old Japanese man with sequential metachronous isolation of <i>A. flavus</i>, <i>A. terreus</i>, and <i>A. fumigatus</i>. Initially presenting with symptoms of productive cough and pulmonary infiltration, the patient experienced two relapses following treatment with oral prednisolone. Adjustments in therapy, including voriconazole and a tailored corticosteroid regimen, resulted in significant improvement without relapse for over 6 months. This case report highlights the challenges and successful management of ABPA involving multiple <i>Aspergillus</i> species.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01423"},"PeriodicalIF":0.8000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221881/pdf/","citationCount":"0","resultStr":"{\"title\":\"Allergic bronchopulmonary aspergillosis with metachronous isolation of three distinct <i>Aspergillus</i> species.\",\"authors\":\"Yosuke Sasahara, Kentaro Akata, Kei Yamasaki, Takeshi Orihashi, Kazuhiro Yatera\",\"doi\":\"10.1002/rcr2.1423\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease induced by exaggerated immune responses to <i>Aspergillus</i> species. Although ABPA has a high recurrence (48%), its instances with sequential isolation of distinct <i>Aspergillus</i> species are sporadic. Only one case report has documented the metachronous isolation of <i>Aspergillus fumigatus</i> and <i>Aspergillus flavus</i>. However, no reported cases of metachronous isolation involving three distinct <i>Aspergillus</i> species exist. Herein, we report a novel case of a 47-year-old Japanese man with sequential metachronous isolation of <i>A. flavus</i>, <i>A. terreus</i>, and <i>A. fumigatus</i>. Initially presenting with symptoms of productive cough and pulmonary infiltration, the patient experienced two relapses following treatment with oral prednisolone. Adjustments in therapy, including voriconazole and a tailored corticosteroid regimen, resulted in significant improvement without relapse for over 6 months. This case report highlights the challenges and successful management of ABPA involving multiple <i>Aspergillus</i> species.</p>\",\"PeriodicalId\":45846,\"journal\":{\"name\":\"Respirology Case Reports\",\"volume\":\"12 7\",\"pages\":\"e01423\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221881/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respirology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/rcr2.1423\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rcr2.1423","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Allergic bronchopulmonary aspergillosis with metachronous isolation of three distinct Aspergillus species.
Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease induced by exaggerated immune responses to Aspergillus species. Although ABPA has a high recurrence (48%), its instances with sequential isolation of distinct Aspergillus species are sporadic. Only one case report has documented the metachronous isolation of Aspergillus fumigatus and Aspergillus flavus. However, no reported cases of metachronous isolation involving three distinct Aspergillus species exist. Herein, we report a novel case of a 47-year-old Japanese man with sequential metachronous isolation of A. flavus, A. terreus, and A. fumigatus. Initially presenting with symptoms of productive cough and pulmonary infiltration, the patient experienced two relapses following treatment with oral prednisolone. Adjustments in therapy, including voriconazole and a tailored corticosteroid regimen, resulted in significant improvement without relapse for over 6 months. This case report highlights the challenges and successful management of ABPA involving multiple Aspergillus species.
期刊介绍:
Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.