以治愈性切除术治疗的胃癌复发部位的预后相关性:一项单中心回顾性研究

IF 3.2 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Masato Hayashi, Takeshi Fujita, Hisayuki Matsushita
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引用次数: 0

摘要

目的:接受根治性切除治疗的胃癌有多种复发模式。腹膜是最常见的复发部位。一些报告显示,复发部位不同对其他癌症(如食管癌和结直肠癌)的预后影响也不同。本研究探讨了复发部位是否影响复发性胃癌患者的预后:回顾性分析了115例治愈性胃切除术后肿瘤复发患者的资料。复发部位分为四组:淋巴结(LN)、腹膜、其他单一器官和多发病灶。比较了不同复发部位的临床病理特征。还比较了切除后的预后和复发情况:结果:腹膜是38名患者(33%)的主要复发部位。肿瘤分化和病理分期有显著差异。术后生存率差异无统计学意义(危险比[HR]LN:1,腹膜:1.083,其他单一器官:1.025,多发病灶:1.058;P=1):1.058; P=1.00).复发后的生存率有显著差异(LN HR,1;腹膜 HR,2.164;其他单一器官 HR,1.092;多个病灶 HR,1.554;P=0.01),腹膜和多个病灶复发的患者预后较差。此外,腹膜复发的时间似乎晚于其他部位;LN、腹膜、其他单器官和多发病变复发的中位时间分别为265天、722天、372天和325天:胃癌复发的部位可能对预后有不同的影响。结论:胃癌复发的部位可能对预后有不同的影响,腹膜复发可能对化疗的敏感性较低,且发生在复发的晚期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic Relevance of Recurrent Sites of Gastric Cancer Treated With Curative Resection: A Single Center Retrospective Study.

Purpose: Gastric cancer treated with curative resection exhibits several recurrence patterns. The peritoneum is the most common site of recurrence. Some reports have indicated different prognostic influences according to the recurrence sites in other cancers, such as esophageal and colorectal cancers. This study investigated whether the recurrence sites influenced the prognosis of patients with recurrent gastric cancer.

Materials and methods: The data of 115 patients who experienced tumor recurrence after curative gastrectomy were retrospectively reviewed. The sites of recurrence were divided into 4 groups: lymph node (LN), peritoneum, other single organs, and multiple lesions. Clinicopathological features were compared between the sites of recurrence. Prognosis after resection and recurrence were also compared.

Results: The peritoneum was the primary site of recurrence in 38 patients (33%). The tumor differentiation and pathological stages were significantly different. Survival after surgery did not show a statistically significant difference (hazard ratio [HR] of LN: 1, peritoneum: 1.083, other single organs: 1.025, and multiple lesions: 1.058; P=1.00). Survival after recurrence was significantly different (HR of LN, 1; peritoneum, 2.164; other single organs, 1.092; multiple lesions, 1.554; P=0.01), and patients with peritoneal and multiple lesion recurrences had worse prognosis. Furthermore, peritoneal recurrence seemed to occur later than that at other sites; the median times to recurrence in LN, peritoneal, other single-organ, and multiple lesions were 265, 722, 372, and 325 days, respectively.

Conclusions: The sites of gastric cancer recurrence may have different prognostic effects. Peritoneal recurrence may be less sensitive to chemotherapy and occur during the late phase of recurrence.

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来源期刊
Journal of Gastric Cancer
Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
4.30
自引率
12.00%
发文量
36
期刊介绍: The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.
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