利用纳米材料开发新一代疫苗:最新进展、可能性与挑战》。

IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL
Shamitha Shetty, Pablo Cordero Alvarado, Deleah Pettie, Joel H Collier
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引用次数: 0

摘要

纳米材料因其可调整性和适应性,正成为疫苗开发的重要工具。纳米材料的独特性质为调节通过各种组织的运输、补充或增强佐剂活性以及指定抗原效价和显示提供了机会。这种多功能性使得最近设计出的纳米材料疫苗可用于多种疾病,包括癌症、炎症性疾病和各种传染性疾病。最近,纳米颗粒疫苗在 2019 年冠状病毒病(COVID-19)大流行期间取得的成功进一步激发了人们的热情。本综述总结了纳米疫苗在传染病、癌症、炎症性疾病、过敏性疾病和纳米佐剂方面的最新进展。此外,还讨论了这一类独特材料的临床转化所面临的挑战和机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges.

Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate trafficking through various tissues, complement or augment adjuvant activities, and specify antigen valency and display. This versatility has enabled recent work designing nanomaterial vaccines for a broad range of diseases, including cancer, inflammatory diseases, and various infectious diseases. Recent successes of nanoparticle vaccines during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, the most recent developments in nanovaccines for infectious disease, cancer, inflammatory diseases, allergic diseases, and nanoadjuvants are summarized. Additionally, challenges and opportunities for clinical translation of this unique class of materials are discussed.

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来源期刊
Annual Review of Biomedical Engineering
Annual Review of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
18.80
自引率
0.00%
发文量
14
期刊介绍: Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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