ENPP1基因rs1044498多态性与2型糖尿病风险的相关性：元分析。

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-16 Epub Date: 2024-07-04 DOI:10.1620/tjem.2024.J057

Chunlin Li, Li Liu

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引用次数: 0

摘要

2型糖尿病（T2DM）是一种常见的代谢性疾病，由核苷酸焦磷酸酶磷酸二酯酶1 （ENPP1）调控。ENPP1的功能多态性（rs1044498, K121Q）已被发现与T2DM易感性有关。本研究旨在分析ENPP1 rs1044498多态性与T2DM风险的联合关系。我们检索了2010年1月至2023年12月在Embase、Medline、EBSCO、PubMed、中国知网（CNKI）和万方数据库中的出版物。使用随机效应或固定效应模型分析合并关联强度，并以95%置信区间（ci）的组合优势比（ORs）表示。数据分析采用stat12.0软件。由于异质性高，采用随机效应模型进行计算。在总体人群中，ENPP1 rs1044498与T2DM易感性增加有显著相关，在以下模型中：Q vs. K （OR = 1.405, 95% CI = 1.059 ~ 1.863）、KQ + QQ vs. KK （OR = 1.475, 95% CI = 1.075 ~ 2.023）、QQ vs. KK + KQ （OR = 2.355, 95% CI = 1.302 ~ 4.262）、QQ vs. KK （OR = 3.096, 95% CI = 1.393 ~ 6.882）和KQ vs. KK （OR = 1.399, 95% CI = 1.038 ~ 1.885）。在种族亚群中，rs1044498与亚洲人T2DM风险相关的模型如下：Q vs. K （OR = 1.480, 95% CI = 1.017-2.154）、KQ + QQ vs. KK （OR = 1.578, 95% CI = 1.047-2.379）、QQ vs. KK+ KQ （OR = 3.709, 95% CI = 1.727-7.967）、QQ vs. KK （OR = 5.049, 95% CI = 1.784-16.397）和KQ vs. KK （OR = 1.478, 95% CI = 1.008-2.167）。在诊断标准未显示亚组和血浆亚组中发现rs1044498与T2DM风险之间的明显关联。该研究显示出高敏感性和最小的发表偏倚。enpp1121q等位基因是2型糖尿病的危险因素，尤其是在亚洲人群中。

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Correlation Between ENPP1 Gene rs1044498 Polymorphism with the Risk of Type 2 Diabetes Mellitus: A Meta-analysis.

As a common metabolic disease, type 2 diabetes mellitus (T2DM) is regulated by the ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). A functional polymorphism of ENPP1 (rs1044498, K121Q) has been found to contribute to T2DM susceptibility. This study aims to analyze the combined association of ENPP1 rs1044498 polymorphism with T2DM risk. We searched for publications in Embase, Medline, EBSCO, PubMed, China National Knowledge Infrastructure (CNKI), and Wanfang databases from January 2010 to December 2023. Pooled association strength was analyzed using either a random-effects or fixed-effects model, and expressed as combined odds ratios (ORs) with 95% confidence intervals (CIs). Data analysis was performed by STAT 12.0. Due to high heterogeneity, a random-effects model was used for the calculation. In the total population, ENPP1 rs1044498 was evidently related to an increased susceptibility to T2DM under the following models: Q vs. K (OR = 1.405, 95% CI = 1.059-1.863), KQ + QQ vs. KK (OR = 1.475, 95% CI = 1.075-2.023), QQ vs. KK + KQ (OR = 2.355, 95% CI = 1.302-4.262), QQ vs. KK (OR = 3.096, 95% CI = 1.393-6.882) and KQ vs. KK (OR = 1.399, 95% CI = 1.038-1.885). In ethnic subgroups, rs1044498 was associated with T2DM risk in Asians under the following models: Q vs. K (OR = 1.480, 95% CI = 1.017-2.154), KQ + QQ vs. KK (OR = 1.578, 95% CI = 1.047-2.379), QQ vs. KK+ KQ (OR = 3.709, 95% CI = 1.727-7.967), QQ vs. KK (OR = 5.049, 95% CI = 1.784-16.397) and KQ vs. KK (OR = 1.478, 95% CI = 1.008-2.167). The distinct association between rs1044498 and T2DM risk was discovered in the diagnostic criteria not shown subgroup and plasma subgroup. This study demonstrated high sensitivity with minimal publication bias. The ENPP1 121Q allele is a risk factor for T2DM, particularly in the Asian population.

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来源期刊

Tohoku Journal of Experimental Medicine 医学-医学：内科

CiteScore

3.60

自引率

4.50%

发文量

171

审稿时长

1 months

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