通过文献计量学和可视化分析,探讨肠道微生物群与非酒精性脂肪肝之间关系的全球研究趋势。

IF 4.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Sa'ed H Zyoud, Samer O Alalalmeh, Omar E Hegazi, Muna Shakhshir, Faris Abushamma, Samah W Al-Jabi
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引用次数: 0

摘要

背景:人们日益认识到非酒精性脂肪肝(NAFLD)是一个重要的健康问题。新近的研究集中于肠道微生物群在非酒精性脂肪肝中的作用,强调肠道-肝脏轴。本研究旨在确定关键的研究趋势,并为这一不断发展的领域的未来研究提供指导:这项文献计量学研究利用 Scopus 分析了全球有关肠道微生物群与非酒精性脂肪肝之间联系的研究。该方法采用的搜索策略侧重于文章标题中的相关关键词,并通过仅收录同行评审期刊论文的方式加以完善。数据分析包括文献计量指标,如发表数量和趋势,并使用 VOSviewer 软件 1.6.20 版进行可视化的网络和共现分析,突出关键研究集群和新兴主题:在479篇关于肠道微生物群和非酒精性脂肪肝的论文中,大部分是原创文章(n = 338;70.56%),其次是综述(n = 119;24.84%)。年发表论文数从2010年的1篇增加到2022年的118篇,从2017年开始进入显著增长阶段(R2 = 0.9025,P 结论):这项研究有效地描绘了有关肠道微生物群-NAFLD 关系的不断增长的研究体量,揭示了自 2017 年以来论文数量的显著增长。人们对肠道微生物群和非酒精性脂肪肝的研究兴趣浓厚,主要由中国和美国主导,关注领域各不相同。最近,该领域已转向探索饮食、生活方式和肠道-肝脏轴之间的相互联系。我们假设,随着先进技术的发展,个性化医疗和全面了解非酒精性脂肪肝的新机遇将会出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An examination of global research trends for exploring the associations between the gut microbiota and nonalcoholic fatty liver disease through bibliometric and visualization analysis.

Background: Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a significant health issue. Emerging research has focused on the role of the gut microbiota in NAFLD, emphasizing the gut-liver axis. This study aimed to identify key research trends and guide future investigations in this evolving area.

Methods: This bibliometric study utilized Scopus to analyze global research on the link between the gut microbiota and NAFLD. The method involved a search strategy focusing on relevant keywords in article titles, refined by including only peer-reviewed journal articles. The data analysis included bibliometric indicators such as publication counts and trends, which were visualized using VOSviewer software version 1.6.20 for network and co-occurrence analysis, highlighting key research clusters and emerging topics.

Results: Among the 479 publications on the gut microbiota and NAFLD, the majority were original articles (n = 338; 70.56%), followed by reviews (n = 119; 24.84%). The annual publication count increased from 1 in 2010 to 118 in 2022, with a significant growth phase starting in 2017 (R2 = 0.9025, p < 0.001). The research was globally distributed and dominated by China (n = 231; 48.23%) and the United States (n = 90; 18.79%). The University of California, San Diego, led institutional contributions (n = 18; 3.76%). Funding was prominent, with 62.8% of the articles supported, especially by the National Natural Science Foundation of China (n = 118; 24.63%). The average citation count was 43.23, with an h-index of 70 and a citation range of 0 to 1058 per article. Research hotspots shifted their focus post-2020 toward the impact of high-fat diets on NAFLD incidence.

Conclusions: This study has effectively mapped the growing body of research on the gut microbiota-NAFLD relationship, revealing a significant increase in publications since 2017. There is significant interest in gut microbiota and NAFLD research, mainly led by China and the United States, with diverse areas of focus. Recently, the field has moved toward exploring the interconnections among diet, lifestyle, and the gut-liver axis. We hypothesize that with advanced technologies, new opportunities for personalized medicine and a holistic understanding of NAFLD will emerge.

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来源期刊
Gut Pathogens
Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY
CiteScore
7.70
自引率
2.40%
发文量
43
期刊介绍: Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).
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