Demis Ferreira de Melo, Larissa Pereira Alves, Natália Millena Silva, Laysa Creusa Paes Barreto Barros Silva, Bruna Fernanda de Lima Arruda Holanda, Myla Lôbo de Souza, Larissa Araújo Rolim, Pedro José Rolim Neto
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引用次数: 0
摘要
背景：被忽视热带病（NTD）是主要影响边缘化人群的慢性传染病。可用于治疗 NTD 的化疗药物既有限又过时，这给控制和根除这些疾病带来了挑战。而制药业对资助开发新的替代治疗药物缺乏兴趣，更加剧了这一问题。此外，相当多用于 NTD 治疗的药物水溶性较低。为了解决这一问题，可以采用提高溶解度的策略，如使用环糊精（CD）包合复合物：因此，本系统综述旨在介绍 CD 与药物和化疗化合物复合物的应用，这些复合物用于治疗全球最流行的一些非传染性疾病，以及这些复合物如何提高这些疾病的治疗效果：检索使用了两个文献数据库：Science Direct 和 PubMed。研究的选择和本系统综述的撰写遵循了 PRISMA 指南所规定的标准：结果：在总共 978 篇文章中，有 23 篇在应用了排除标准后被选中。所有被选中的研究均符合将 CD 作为一种策略来提高用于 NTD 的治疗药物的溶解度：结果表明，CD 可以提高用于治疗被忽视热带病（NTD）的化疗药物的溶解度。本综述提供的数据清楚地强调了 CD 在开发治疗被忽视热带病的新疗法方面的潜在用途。它有助于未来制定更有效、更安全的治疗方法。
Cyclodextrins as a Strategy for Enhancing Solubility of Therapeutic Agents for Neglected Tropical Diseases: A Systematic Review.
Background: Neglected Tropical Diseases (NTD) are chronic infectious conditions that primarily affect marginalized populations. The chemotherapeutic arsenal available for treating NTD is limited and outdated, which poses a challenge in controlling and eradicating these diseases. This is exacerbated by the pharmaceutical industry's lack of interest in funding the development of new therapeutic alternatives. In addition, a considerable number of drugs used in NTD therapy have low aqueous solubility. To address this issue, solubility enhancement strategies, such as the use of inclusion complexes with cyclodextrins (CD) can be employed.
Objective: Therefore, this systematic review aims to present the application of CD in complexing with drugs and chemotherapeutic compounds used in the therapy of some of the most prevalent NTD worldwide and how these complexes can enhance the treatment of these diseases.
Methods: Two bibliographic databases, Science Direct and PubMed, were used to conduct the search. The selection of studies and the writing of this systematic review followed the criteria outlined by the PRISMA guidelines.
Results: From a total of 978 articles, 23 were selected after applying the exclusion criteria. All the studies selected were consistent with the use of CD as a strategy to increase the solubility of therapeutic agents used in NTD.
Conclusion: The results indicate that CD can enhance the solubility of chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTD). This review presents data that clearly highlights the potential use of CD in the development of new treatments for neglected tropical diseases. It can assist in the formulation of future treatments that are more effective and safer.
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Aims & Scope
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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