STIM1:核动力学的新角色?从肾小管聚集性肌病中汲取的教训

IF 4.3 2区 生物学 Q2 CELL BIOLOGY
Emanuela Pessolano , Zlata A. Sosic , Armando A. Genazzani
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引用次数: 0

摘要

最近的两篇论文强调,STIM1 是储存器操作的 Ca2+ 进入的关键成分,它能够转位到细胞核,并参与核 Ca2+ 处理和 DNA 修复。这些发现为研究这种 Ca2+ 传感蛋白在健康和疾病中可能发挥的作用开辟了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy

STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy

Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2+-entry, is able to translocate to the nucleus and participate in nuclear Ca2+-handling and in DNA repair. These finding opens new avenues on the role that this Ca2+-sensing protein may have in health and disease.

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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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