Emanuela Pessolano , Zlata A. Sosic , Armando A. Genazzani
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引用次数: 0
摘要
最近的两篇论文强调,STIM1 是储存器操作的 Ca2+ 进入的关键成分,它能够转位到细胞核,并参与核 Ca2+ 处理和 DNA 修复。这些发现为研究这种 Ca2+ 传感蛋白在健康和疾病中可能发挥的作用开辟了新的途径。
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy
Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2+-entry, is able to translocate to the nucleus and participate in nuclear Ca2+-handling and in DNA repair. These finding opens new avenues on the role that this Ca2+-sensing protein may have in health and disease.
期刊介绍:
Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include:
Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling
Influence of calcium regulation in affecting health and disease outcomes