zAvatars通过测试

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES
Alexandra Le Bras
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引用次数: 0

摘要

手术是治疗结直肠癌的主要方式,大约 50%的患者可以通过手术治愈。然而,术后复发是一个大问题,患者可从术后系统疗法中获益匪浅。然而,为患者找到最佳疗法可能具有挑战性,会导致不必要的副作用和宝贵时间的损失。在一项新研究中,Champalimaud 基金会的 Rita Fior 实验室利用他们之前描述的斑马鱼患者衍生异种移植模型(zAvatar)提出了一个快速预测平台,以指导结直肠癌的个性化治疗。在这项试验中,研究人员将荧光标记的患者肿瘤细胞注射到受精后两天的斑马鱼胚胎中,然后用与相应患者相同的疗法治疗斑马鱼。注射后三天(治疗后两天),研究小组通过分析凋亡、肿瘤大小和转移潜力等读数,评估ZAvatar对治疗的反应,并与未治疗的ZAvatar对照组进行比较。将每个zAvatar测试与相应患者的化疗反应进行比较后发现,zAvatars预测患者病情进展的准确率高达91%。这个新平台可以补充其他小鼠和细胞模型,帮助指导临床决策和优化癌症患者的治疗方案:Costa, B. et al.Nat.15, 4771 (2024)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
zAvatars pass the test
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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