细胞搭便车指南:阿尔法疱疹病毒外壳中的世界》(A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses)。

IF 8.1 1区 医学 Q1 VIROLOGY
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1146/annurev-virology-100422-022751
Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik
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引用次数: 0

摘要

核质、细胞质、病毒内部以及细胞质构成了阿尔法疱疹病毒的囊膜遇到病毒和宿主蛋白的世界,这些蛋白支持或限制它们执行任务。在这里,我们将回顾阿尔法疱疹病毒感染后期特定蛋白质与蛋白质之间的相互作用是如何协调囊体核组装、核排出和细胞质包膜的,以及如何将进入的囊体引向幼稚细胞的核孔,从而将病毒基因组注入核质进行病毒转录和复制的这一引人入胜的难题。利用病毒突变体和重构感染周期关键阶段的检测方法,研究人员确定了病毒与病毒和宿主蛋白之间多种噬菌体相互作用的特征。角质细胞、成纤维细胞、粘膜上皮细胞、神经元和免疫细胞利用细胞类型特异的内在和细胞因子诱导的抵抗机制来限制病毒感染周期的几个阶段。然而,与此同时,α-疱疹病毒也进化出了应对措施,以确保在感染过程中有效地发挥囊壳功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses.

The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world in which the capsids of alphaherpesviruses encounter viral and host proteins that support or limit them in performing their tasks. Here, we review the fascinating conundrum of how specific protein-protein interactions late in alphaherpesvirus infection orchestrate capsid nuclear assembly, nuclear egress, and cytoplasmic envelopment, but target incoming capsids to the nuclear pores in naive cells to inject the viral genomes into the nucleoplasm for viral transcription and replication. Multiple capsid interactions with viral and host proteins have been characterized using viral mutants and assays that reconstitute key stages of the infection cycle. Keratinocytes, fibroblasts, mucosal epithelial cells, neurons, and immune cells employ cell type-specific intrinsic and cytokine-induced resistance mechanisms to restrict several stages of the viral infection cycle. However, concomitantly, alphaherpesviruses have evolved countermeasures to ensure efficient capsid function during infection.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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