肺鳞癌在初次治疗六年后对尼伐单抗再治疗产生反应:病例报告。

IF 2.3 3区 医学 Q3 ONCOLOGY
Thoracic Cancer Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI:10.1111/1759-7714.15267
Kento Kono, Kazuhisa Nakashima, Yukari Tsubata, Yoshihiro Amano, Keita Kawakado, Takashi Yanagawa, Takeshi Isobe
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引用次数: 0

摘要

一名 61 岁的男子以慢性咳嗽为主诉来我院就诊。他被诊断为肺鳞癌,临床分期为 cT2aN3M1a。他接受了四线化疗,但原发肿瘤和淋巴结转移灶均增大。尼妥珠单抗(Nivolumab)作为第五线治疗,使他获得了持续 2 年零 8 个月的完全应答(CR)。由于出现了通用术语标准的不良事件 1 级肺炎,治疗被迫停止。他在未接受治疗的情况下接受了 3 年零 8 个月的随访,但出现了左锁骨上窝淋巴结转移。患者开始接受 nivolumab 再治疗,并再次达到 CR。再治疗 1 年零 6 个月后,患者使用 nivolumab 治疗后再次获得 CR。该病例是一个罕见的例子,即在延长了无免疫检查点抑制剂(ICI)的间隔期后,nivolumab 产生了显著的反应。我们的经验表明,对 ICIs 的长期反应在未来可能会恶化。因此,在初始治疗成功的情况下,使用 ICIs 进行再治疗可能是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lung squamous cell carcinoma responding to nivolumab retreatment six years after initial treatment: A case report.

A 61-year-old man presented to our hospital with a chief complaint of chronic cough. He was diagnosed with lung squamous cell carcinoma at clinical stage cT2aN3M1a. He received chemotherapy up to the fourth line, but both the primary tumor and lymph node metastases increased in size. Nivolumab, administered as the fifth line, resulted in a complete response (CR) that continued for 2 years and 8 months. Treatment was stopped due to the appearance of common terminology criteria for adverse events grade 1 pneumonitis. He was followed up without treatment for 3 years and 8 months, but a left supraclavicular fossa lymph node metastasis appeared. Retreatment with nivolumab was initiated, and the patient achieved CR again. One year and 6 months after retreatment, CR was maintained with nivolumab. This case represents a rare instance in which nivolumab yielded a significant response after a prolonged immune checkpoint inhibitor (ICI)-free interval. Our experience has shown that the long-term response to ICIs may deteriorate in the future. Therefore, retreatment with ICIs may be effective when the initial therapy is successful.

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来源期刊
Thoracic Cancer
Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM
CiteScore
5.20
自引率
3.40%
发文量
439
审稿时长
2 months
期刊介绍: Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.
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