对乙酰氨基酚诱发的高阴离子间隙代谢性酸中毒：一种常见药物可能导致的认识不足的后果。

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-01-01 Epub Date: 2024-07-02 DOI:10.1007/s00467-024-06396-4

Dhruv Gaur, Michael G Michalopulos, Keri A Drake, Jyothsna Gattineni

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引用次数: 0

摘要

代谢性酸中毒是慢性肾脏病（CKD）患者最常见的并发症之一，但有几种不常见的病因却很难诊断。在这里，我们描述了一名腹膜透析患者因服用对乙酰氨基酚导致5-氧代脯氨酸血症，继发高阴离子间隙代谢性酸中毒。虽然慢性肾功能衰竭是导致这种潜在严重并发症的一个已知风险因素，但本病例进一步强调了即使对乙酰氨基酚为治疗剂量，5-氧代脯氨酸的蓄积也可能发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.

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Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.

While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.