P2RX4 多态性与 2 型糖尿病的关系：一项初步病例对照研究。

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2025-01-01 Epub Date: 2024-07-02 DOI:10.1080/15257770.2024.2373300

Homa Noori, Mahdi Majidpour, Mahboobeh Sabeti Akbar-Abad, Ramin Saravani

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引用次数: 0

摘要

目的：2型糖尿病（T2DM）是一种病因复杂的异源代谢性疾病。嘌呤能受体在不同的过程中起着关键作用，并被推测在 T2DM 的发病机制中发挥作用：采用扩增难治性突变系统聚合酶链反应（ARMS-PCR）对 300 名 T2DM 患者和 300 名健康受试者进行基因分型。采用 SPSS V16.0 进行统计分析：研究结果表明，在我国人群中，rs25644A > G 的 G 等位基因会增加 T2DM 的患病风险（OR = 1.51，95% CI = 1.14-1.99，P = 0.003）。在一些基因型模型（包括显性模型）中，该等位基因导致 T2DM 风险增加。所研究的 P2XR4 基因变异之间的基因型相互作用增加了 T2DM 的风险。单倍型分析表明，Ars1169727/Grs25644单倍型导致T2DM风险增加：结论：研究结果表明，rs25644A > G 在我国人群 T2DM 风险增加中起作用。

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Association of polymorphisms within P2RX4 with type 2 diabetes mellitus: a preliminary case-control study.

Objective: Type 2 diabetes mellitus (T2DM) is a complex heterogenic metabolic with a wide range of etiology. Purinergic receptors have pivotal roles in different processes and are hypothesized to have roles in the pathogenesis of T2DM.

Materials and methods: Three hundred subjects affected by T2DM and 300 healthy subjects were genotyped by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). SPSS V16.0 was recruited for statistical analysis.

Results: The findings showed that the G allele of rs25644A > G increases the risk of T2DM in our population statistically (OR = 1.51, 95% CI = 1.14-1.99, p = 0.003). This allele in some genotype models, including the dominant model, caused an increase in the risk of T2DM. The interaction of genotypes between studied variants in the P2XR4 gene increased the risk of T2DM. Haplotype analysis showed that A_rs1169727/G_rs25644 haplotype caused an increase in the risk of T2DM.

Conclusions: The findings suggest that rs25644A > G plays a role in our population's increased risk of T2DM.

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来源期刊

Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

6 months

期刊介绍： Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.