镁在帕金森病中的神经保护潜力。

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Somdattaa Ray
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引用次数: 0

摘要

帕金森病(PD)的发病机制是多方面的,包括α突触核蛋白聚集、活性氧(ROS)产生的氧化应激、线粒体功能障碍、细胞凋亡、微量元素失衡以及内质网应激和炎症。铁、镁和钙等二价阳离子平衡的改变与帕金森病的发病机制有关。低水平的镁与多巴胺能细胞在帕金森病动物模型中的加速丧失有关,而镁已被证明在帕金森病模型中具有神经保护作用。有证据表明,帕金森病患者大脑中的镁含量低,而饮食中的镁含量低会增加患帕金森病的风险,这进一步加强了镁缺乏在帕金森病发病机制中的作用。脑组织中的镁含量较低,而脑脊液和血清中的镁含量较高,这支持了镁转运体功能障碍在帕金森病中的可能性。事实上,最近在帕金森病患者中发现了镁转运通道的变异,如TRPM7和SLC41A1。镁是一种 NMDA 拮抗剂,对左旋多巴诱发的运动障碍也有治疗作用。目前还没有临床研究表明镁对帕金森病有神经保护作用,但地中海饮食及其变体与帕金森病的低风险相关,这可能是由于饮食中富含镁。进一步的临床试验包括优化通道功能的治疗模型,再加上高镁饮食,可能会为治疗帕金森氏症的神经保护性干预铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The neuroprotective potential of magnesium in Parkinson's disease.

Pathogenic mechanisms implicated in the development of Parkinson disease (PD) are multifaceted and include alpha synuclein aggregation, oxidative stress due to generation of reactive oxygen species (ROS), mitochondrial dysfunction, apoptosis, imbalance of trace elements as well as endoplasmic reticulum stress, and inflammation. Alteration in the homeostasis of bivalent cations, such as iron, magnesium and calcium, has been implicated in the pathogenesis of PD. Low levels of magnesium have been associated with accelerated dopaminergic cell loss in animal PD models, and magnesium has been shown to have a neuroprotective effect in PD models. Evidence of a low magnesium level in the brain of PD individuals, with a low magnesium level in the diet, increasing the risk of PD, further strengthens the role of magnesium deficiency in the pathogenesis of PD. The presence of low-level magnesium in brain tissue and high level in CSF and serum support the possibility of dysfunctional magnesium transporters in PD. Indeed, variants in magnesium transport channels, such as TRPM7 and SLC41A1, have been recently detected in PD individuals. Magnesium, being an NMDA antagonist, could also have a therapeutic role in levodopa-induced dyskinesia. There are no clinical studies indicating a neuroprotective role of magnesium in PD, however, the Mediterranean diet and variants of the diet have been associated with a lower risk of PD, which may be due to the magnesium-rich constituents of the diet. Further clinical trials encompassing therapeutic models to optimize channel function, coupled with a high magnesium diet, may pave the way for promising neuroprotective intervention for PD.

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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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