非格列酮:谁应该为慢性肾脏病患者开处方?助理医师的观点。

IF 2.7 4区 医学 Q2 UROLOGY & NEPHROLOGY
Becky M Ness, Heidi Webb
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引用次数: 0

摘要

糖尿病肾病(DKD)患者占糖尿病患者总数的 30-40%,是慢性肾病(CKD)心血管负担的重要组成部分。尽管已有非格列酮等循证药物和尿白蛋白肌酐比(UACR)等简单的筛查测试,但仍需要更多的资源来护理 DKD 患者。医生助理(PA)在负责 DKD 诊断、监测和管理的多学科团队中发挥着至关重要的作用。非甾体类矿物质皮质激素受体拮抗剂,即非格列酮(fineerenone),已获得美国食品及药物管理局(FDA)批准,用于治疗伴有 2 型糖尿病的慢性肾脏病成人患者,以降低肾脏和心血管疾病的风险。非格列酮被认为是治疗 DKD 的主要药物之一,此外,将非格列酮与肾素-血管紧张素系统抑制剂和/或其他肾脏保护药物联合使用可能会带来更多益处。与专科医疗服务提供者相比,初级医疗服务提供者处方非格列酮的频率较低,这表明有必要在药物处方和其他肾脏保护策略方面增强医生助理的能力。作为多学科团队的一部分,医生助理可以在评估导致心脏病和代谢健康的风险因素方面发挥重要作用。他们不仅可以通过每 3-12 个月进行一次血清肌酐和尿白蛋白-肌酐比值等检查来监测肾功能,还可以监测血清钾水平。此外,医生还可以鼓励患者定期监测血压、血糖水平和体重,为自己的健康负责。通过早期发现和管理,肾衰竭和心血管事件是可以预防的。专科医生助理在 DKD 患者的全面护理中也发挥着重要作用,尤其是在后期阶段。DKD 护理可能会受到许多因素的阻碍,如患者在咨询过程中缺乏参与、费用差异以及复杂的转诊系统,这些都需要多学科指南来改善专业沟通。有必要重新认识助理医师在初级保健中的作用,并赋予他们目标导向疗法的权力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Finerenone: Who should prescribe it for CKD? The physician associate's perspective.

Finerenone: Who should prescribe it for CKD? The physician associate's perspective.

Diabetic kidney disease (DKD) affects 30-40% of all patients with diabetes and contributes significantly to the cardiovascular burden of chronic kidney disease (CKD). Despite the availability of evidence-based medications like finerenone and simple screening tests such as Urinary Albumin-to-Creatinine Ratio (UACR), more resources are still needed to care for DKD patients. Physician Associates (PAs) play a crucial role in the multidisciplinary team responsible for DKD diagnosis, monitoring, and management. A nonsteroidal mineralocorticoid receptor antagonist, namely finerenone, was approved by the FDA in adults with CKD associated with type 2 diabetes to reduce the risk of renal and cardiovascular outcomes. Finerenone is considered among the pillars of care for DKD, furthermore, the addition of finerenone in combination with renin-angiotensin system inhibitors and/or other renal protective medications may offer additional benefits. Primary care providers prescribe finerenone less frequently than specialized care providers, indicating a need to empower physician associates in medication prescription and other renal protection strategies. As part of a multidisciplinary team, physician associates can play an important role in evaluating risk factors that contribute to heart disease and metabolic health. They can also monitor not only kidney function by ordering tests, such as serum creatinine and urinary albumin-to-creatinine ratio every 3-12 months, but also serum potassium levels. Additionally, physician associates can encourage patients to take responsibility for their health by regularly monitoring their blood pressure, blood glucose levels, and body weight. With early detection and management, kidney failure and cardiovascular events may be preventable. Specialized physician associates also play a significant role in the comprehensive care of DKD patients, especially in the later stages. DKD care can be hindered by numerous factors such as lack of patient engagement during counseling, cost disparities, and a complex referral system that requires multidisciplinary guidelines to improve professional communication. It is necessary to re-envision the physician associates' role in primary care and empower them in goal-directed therapies.

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来源期刊
Journal of Nephrology
Journal of Nephrology 医学-泌尿学与肾脏学
CiteScore
5.60
自引率
5.90%
发文量
289
审稿时长
3-8 weeks
期刊介绍: Journal of Nephrology is a bimonthly journal that considers publication of peer reviewed original manuscripts dealing with both clinical and laboratory investigations of relevance to the broad fields of Nephrology, Dialysis and Transplantation. It is the Official Journal of the Italian Society of Nephrology (SIN).
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