用于检测 Fe3+ 和 Pb2+ 离子的硝基喹诺酮融合水杨酰和萘腙荧光探针。

IF 3.1 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Journal of Fluorescence Pub Date : 2025-06-01 Epub Date: 2024-07-02 DOI:10.1007/s10895-024-03813-7
Vandana Nandakumar, Sentamil Selvi Ramasamy, Kaviyarasu Adhigaman, Narmatha Ganesan, Divyakaaviri Subramani, Shankar Ramasamy, Raju Nandhakumar, Suresh Thangaraj
{"title":"用于检测 Fe3+ 和 Pb2+ 离子的硝基喹诺酮融合水杨酰和萘腙荧光探针。","authors":"Vandana Nandakumar, Sentamil Selvi Ramasamy, Kaviyarasu Adhigaman, Narmatha Ganesan, Divyakaaviri Subramani, Shankar Ramasamy, Raju Nandhakumar, Suresh Thangaraj","doi":"10.1007/s10895-024-03813-7","DOIUrl":null,"url":null,"abstract":"<p><p>The application of quinolones stretches over a large umbrella of medicinal field as well as chemosensor due to the presence of privileged heterocyclic aromatic rig system. Salicyl and Naphthyl Hydrazide motifs are also established fluorophore groups. Therefore in this work, we have designed and synthesized Salicyl hydrazide (3a-c) and naphthyl hydrazide fused nitroquinolones (5a-c) investigated for their fluorescent behaviour. Preliminary UV- absorption studies were carried out and the metal selectivity were examined with various metal ion. Among them, it was found that compound 3a was selective towards Fe<sup>3+</sup> ions (λ<sub>ex</sub> = 330 nm, 1:1 DMF:H<sub>2</sub>O at pH = 7.4 in HEPES Buffer medium). 3a shows decrease emission intensity in presence of Fe<sup>3+</sup> ions. Compound 5a shows enhancement in fluorescence intensity upon addition of Pb<sup>2+</sup> ion (λ<sub>ex</sub> = 280 nm, 1:1 DMF:H<sub>2</sub>O at pH = 7.4 in HEPES Buffer medium). Further, the concentration dependence, competitive binding and EDTA reversibility were studied for selected compounds towards the respective cations selectivity. Jobs plot analysis indicate that 1:1 binding of 3a with Fe<sup>3+</sup> ion (K<sub>a</sub> = 3.17 x10<sup>4</sup>M<sup>-1</sup> and Limit Of Detection (LOD) = 5.1 × 10<sup>-7</sup> M) whereas 5a showed 1:2 binding mode with Pb<sup>2+</sup> ions (K<sub>a</sub> = 2.14 × 10<sup>6</sup> M<sup>-1</sup> and Limit Of Detection (LOD) = 2.613 × 10<sup>-9</sup> M). Density Function Theoretical studies were performed as support for the experimental results.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":"4129-4142"},"PeriodicalIF":3.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nitroquinolone Fused Salicyl and Naphthyl Hydrazone Fluorescent Probes for the Detection of Fe<sup>3+</sup>and Pb<sup>2+</sup> Ions.\",\"authors\":\"Vandana Nandakumar, Sentamil Selvi Ramasamy, Kaviyarasu Adhigaman, Narmatha Ganesan, Divyakaaviri Subramani, Shankar Ramasamy, Raju Nandhakumar, Suresh Thangaraj\",\"doi\":\"10.1007/s10895-024-03813-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The application of quinolones stretches over a large umbrella of medicinal field as well as chemosensor due to the presence of privileged heterocyclic aromatic rig system. Salicyl and Naphthyl Hydrazide motifs are also established fluorophore groups. Therefore in this work, we have designed and synthesized Salicyl hydrazide (3a-c) and naphthyl hydrazide fused nitroquinolones (5a-c) investigated for their fluorescent behaviour. Preliminary UV- absorption studies were carried out and the metal selectivity were examined with various metal ion. Among them, it was found that compound 3a was selective towards Fe<sup>3+</sup> ions (λ<sub>ex</sub> = 330 nm, 1:1 DMF:H<sub>2</sub>O at pH = 7.4 in HEPES Buffer medium). 3a shows decrease emission intensity in presence of Fe<sup>3+</sup> ions. Compound 5a shows enhancement in fluorescence intensity upon addition of Pb<sup>2+</sup> ion (λ<sub>ex</sub> = 280 nm, 1:1 DMF:H<sub>2</sub>O at pH = 7.4 in HEPES Buffer medium). Further, the concentration dependence, competitive binding and EDTA reversibility were studied for selected compounds towards the respective cations selectivity. Jobs plot analysis indicate that 1:1 binding of 3a with Fe<sup>3+</sup> ion (K<sub>a</sub> = 3.17 x10<sup>4</sup>M<sup>-1</sup> and Limit Of Detection (LOD) = 5.1 × 10<sup>-7</sup> M) whereas 5a showed 1:2 binding mode with Pb<sup>2+</sup> ions (K<sub>a</sub> = 2.14 × 10<sup>6</sup> M<sup>-1</sup> and Limit Of Detection (LOD) = 2.613 × 10<sup>-9</sup> M). Density Function Theoretical studies were performed as support for the experimental results.</p>\",\"PeriodicalId\":15800,\"journal\":{\"name\":\"Journal of Fluorescence\",\"volume\":\" \",\"pages\":\"4129-4142\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fluorescence\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s10895-024-03813-7\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-024-03813-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

摘要

由于喹诺酮类药物中含有特殊的杂环芳香族链节系统,因此其应用领域涵盖了医药领域和化学传感器领域。水杨基和萘甲酰肼基团也是成熟的荧光基团。因此,在这项工作中,我们设计并合成了水杨酰肼(3a-c)和萘酰肼融合硝基喹诺酮(5a-c),并对其荧光行为进行了研究。对它们进行了初步的紫外线吸收研究,并用各种金属离子检测了它们的金属选择性。研究发现,化合物 3a 对 Fe3+ 离子具有选择性(λex = 330 nm,1:1 DMF:H2O,在 pH = 7.4 的 HEPES 缓冲介质中)。3a 在有 Fe3+ 离子存在时发射强度降低。加入 Pb2+ 离子后,化合物 5a 的荧光强度增强(λex = 280 nm,1:1 DMF:H2O,在 pH = 7.4 的 HEPES 缓冲液介质中)。此外,还研究了所选化合物对相应阳离子选择性的浓度依赖性、竞争性结合和 EDTA 可逆性。乔布斯图分析表明,3a 与 Fe3+ 离子的结合比例为 1:1(Ka = 3.17 x104M-1 和检测限 (LOD) = 5.1 × 10-7 M),而 5a 与 Pb2+ 离子的结合比例为 1:2(Ka = 2.14 × 106 M-1 和检测限 (LOD) = 2.613 × 10-9 M)。密度函数理论研究为实验结果提供了支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nitroquinolone Fused Salicyl and Naphthyl Hydrazone Fluorescent Probes for the Detection of Fe<sup>3+</sup>and Pb<sup>2+</sup> Ions.

Nitroquinolone Fused Salicyl and Naphthyl Hydrazone Fluorescent Probes for the Detection of Fe3+and Pb2+ Ions.

The application of quinolones stretches over a large umbrella of medicinal field as well as chemosensor due to the presence of privileged heterocyclic aromatic rig system. Salicyl and Naphthyl Hydrazide motifs are also established fluorophore groups. Therefore in this work, we have designed and synthesized Salicyl hydrazide (3a-c) and naphthyl hydrazide fused nitroquinolones (5a-c) investigated for their fluorescent behaviour. Preliminary UV- absorption studies were carried out and the metal selectivity were examined with various metal ion. Among them, it was found that compound 3a was selective towards Fe3+ ions (λex = 330 nm, 1:1 DMF:H2O at pH = 7.4 in HEPES Buffer medium). 3a shows decrease emission intensity in presence of Fe3+ ions. Compound 5a shows enhancement in fluorescence intensity upon addition of Pb2+ ion (λex = 280 nm, 1:1 DMF:H2O at pH = 7.4 in HEPES Buffer medium). Further, the concentration dependence, competitive binding and EDTA reversibility were studied for selected compounds towards the respective cations selectivity. Jobs plot analysis indicate that 1:1 binding of 3a with Fe3+ ion (Ka = 3.17 x104M-1 and Limit Of Detection (LOD) = 5.1 × 10-7 M) whereas 5a showed 1:2 binding mode with Pb2+ ions (Ka = 2.14 × 106 M-1 and Limit Of Detection (LOD) = 2.613 × 10-9 M). Density Function Theoretical studies were performed as support for the experimental results.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Fluorescence
Journal of Fluorescence 化学-分析化学
CiteScore
4.60
自引率
7.40%
发文量
203
审稿时长
5.4 months
期刊介绍: Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信