甘油三酯-葡萄糖指数作为非糖尿病患者高血压、心脏病和脑梗塞风险的预测指标:2001-2020 年 NHANES 横断面研究》。

IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Bisher Sawaf, Sarya Swed, Hidar Alibrahim, Haidara Bohsas, Tirth Dave, Mohamad Nour Nasif, Wael Hafez, Fatema Ali Asgar Tashrifwala, Yazan Khair Eldien Jabban, Safwan Al-Rassas, Heba Haj Saleh, Abdul Rehman Zia Zaidi, Baraa Alghalyini, Shaymaa Abdelmaboud Mohamed, Waleed Farouk Mohamed, Amr Farwati, Mohammed Najdat Seijari, Naim Battikh, Basma Elnagar, Seema Iqbal, Karla Robles-Velasco, Ivan Cherrez-Ojeda
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引用次数: 0

摘要

背景:心血管疾病(CVD)是导致全球死亡的主要原因。心血管疾病的早期干预和预防取决于对心血管疾病风险的准确预测。本研究旨在调查美国无糖尿病患者的 TyG 指数与冠心病(CHD)、充血性心力衰竭(CHF)、心脏病发作(HA)、中风和高血压(HTN)风险之间的关联:在这项回顾性横断面研究中,我们使用了 2001 年至 2020 年美国国家健康与营养调查(NHANES)的数据。我们建立了多个回归分析模型,并计算了(TyG)指数预测冠心病、冠心病心房颤动、HA、中风和高血压发病的敏感性和特异性:共有 10,937 名未患糖尿病的人参与了我们的研究。TyG指数大于8.96的人,其体重指数(BMI)、收缩压/舒张压、总胆固醇、低密度脂蛋白和载脂蛋白-B水平等各项指标均有显著上升(p 结论:TyG指数与心血管疾病的发病率密切相关:TyG指数与非糖尿病患者的心血管风险因素有很强的相关性,但它几乎不能预测所研究的心血管疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triglyceride-Glucose Index as Predictor for Hypertension, CHD and STROKE Risk among Non-Diabetic Patients: A NHANES Cross-Sectional Study 2001-2020.

Background: Cardiovascular disease (CVD) is a leading cause of global mortality. Early intervention and prevention of CVD depend on accurately predicting the risk of CVD. This study aimed to investigate the association between the TyG index and the risk of coronary heart disease (CHD), congestive heart failure (CHF), heart attack (HA), stroke, and hypertension (HTN) among patients without diabetes in the United States.

Methods: In this retrospective, cross-sectional study, we used data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2020. We conducted several regression analysis models and calculated the sensitivity and specificity of (TyG) index for predicting the onset of CHD, CHF, HA, stroke, and HTN.

Results: A total of 10,937 individuals without diabetes participated in our study. Individuals with a TyG index greater than 8.96 displayed significant increasing in various parameters, including BMI, systolic/diastolic blood pressure, total cholesterol, LDL, and Apo-B levels (p < 0.001). Almost all regression models ensured that a higher TyGI value was associated with higher odds of having CHD, CHF, HA, stroke, and HTN, which patients with a TyGI value higher than 8.96 have odds ratios of 2.24-5.58 for CHD, 1.68-4.42 for stroke, 2.45-3.77 for HA and 1.75-3.93 for HTN comparing than patients with a TyGI value lower than 8.11 (p-value < 0.05).We evaluated the predictive value of the TyG index for each endpoint, obtaining the following area under the curve (AUC) values: 54.75% for CHF (95% CI: 0.542-0.614), 52.32% for stroke (95% CI: 0.529-0.584), 55.67% for HA (95% CI: 0.595-0.646), 55.59% for HTN (95% CI: 0.574-0.597), and 50.31% for CHD (95% CI: 0.592-0.646).

Conclusion: The TyG index showed a strong correlation with cardiovascular risk factors in individuals without diabetes, however it was a poor predictor of almost studied cardiovascular diseases.

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来源期刊
CiteScore
10.70
自引率
1.40%
发文量
57
审稿时长
19 weeks
期刊介绍: The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
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