美国各年龄段恶性卵巢生殖细胞瘤患者的总体治疗情况和模式比较:国家癌症数据库(2004-2016年)分析。

IF 4.1 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Shannon M Sullivan, Sara Stoneham, Michelle Lockley, A Lindsay Frazier, Deborah F Billmire, Jenny N Poynter
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引用次数: 0

摘要

背景:被诊断患有恶性卵巢生殖细胞瘤的≥40岁女性比年轻女性(15-39岁)的预后更差:与年轻女性(15-39 岁)相比,被诊断患有恶性卵巢生殖细胞瘤的≥40 岁女性的预后更差:我们利用美国国家癌症数据库(NCDB)评估了不同年龄组被诊断为四种最常见组织学亚型之一的恶性卵巢生殖细胞瘤患者的治疗模式和总生存率:我们在 NCDB(2004-2016 年)中识别了确诊患有卵巢生殖细胞瘤的 15-90 岁女性。采用 Logistic 回归比较不同年龄组的护理模式、人口统计学特征和疾病特征。Cox比例危险度回归用于评估一系列人口统计学、临床和治疗特征与总生存率之间的关系:共有 2998 名患者被诊断为卵巢生殖细胞瘤四种最常见的组织学亚型之一(未成熟畸胎瘤、胚胎发育不良瘤、卵黄囊肿瘤和混合生殖细胞),其中年龄≥40 岁的患者被诊断为卵巢生殖细胞瘤,年龄≥40 岁的患者被诊断为卵巢生殖细胞瘤,年龄≥40 岁的患者被诊断为卵巢生殖细胞瘤。年龄≥40岁的卵巢生殖细胞瘤患者更有可能合并其他疾病、双侧肿瘤、疾病分期更高、仅接受化疗以及切除后肿瘤残留:研究结果表明,年龄≥40 岁的卵巢生殖细胞肿瘤患者的总生存率低于年龄≥40 岁的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of overall and patterns of care in patients with a malignant ovarian germ cell tumor by age in the United States: a National Cancer Database (2004-2016) analysis.

Background: Women aged ≥40 years diagnosed with a malignant ovarian germ cell tumor are more likely to have poor outcomes than their younger counterparts (aged 15-39 years).

Objective: We used the National Cancer Database (NCDB) to evaluate patterns of care and overall survival for individuals diagnosed with one of the four most common histologic subtypes of malignant ovarian germ cell tumor by age group.

Methods: We identified women aged 15-90 diagnosed with ovarian germ cell tumors in the NCDB (2004-2016). Logistic regression was used to compare patterns of care, demographic, and disease characteristics by age group. Cox proportional hazards regression was used to evaluate associations between a range of demographic, clinical, and treatment characteristics with overall survival.

Results: A total of n=2998 patients who were diagnosed with one of the four most common histologic subtypes (immature teratoma, dysgerminoma, yolk sac tumor, and mixed germ cell) of ovarian germ cell tumor were included in the analysis. Patients aged ≥40 years diagnosed with ovarian germ cell tumors were more likely to have co-morbidities, a bilateral tumor, higher stage of disease, receive chemotherapy only, and have a residual tumor after resection as compared with patients aged <40 years. Moreover, women aged ≥40 years had the highest risk of death (reference: 15-24 year olds; HR=5.37, 95% CI 3.76 to 7.66) after adjustment for demographic characteristics, tumor histology, and treatment received. In stratified analyses, women aged ≥40 years had significantly worse overall survival at each disease stage and histologic subtype.

Conclusion: Findings suggest that women aged ≥40 years who are diagnosed with ovarian germ cell tumors have worse overall survival than those aged <40, independent of stage, disease characteristics, and treatment. Our study highlights the need for future research to better understand reasons for poorer outcomes in women aged ≥40 years.

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来源期刊
CiteScore
6.60
自引率
10.40%
发文量
280
审稿时长
3-6 weeks
期刊介绍: The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.
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