{"title":"关于运动干预阿尔茨海默病的系统性综述的证据图谱和质量评估。","authors":"Zhengdong Xu , Jiaxing Tang , Wenjuan Yi","doi":"10.1016/j.ctim.2024.103065","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>A significant body of literature suggests that exercise can reverse cognitive impairment and ameliorate somatic function in patients with Alzheimer's disease (AD). Systematic reviews (SRs), a common approach of evidence-based medicine, concentrate on a specific issue of a research area. The objective of this work is to provide an overview of existing evidence on the effects of exercise intervention in AD patients and report related health outcomes by reviewing SRs.</p></div><div><h3>Methods</h3><p>SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.</p></div><div><h3>Results</h3><p>A total of 26 SRs met the eligibility criteria. In terms of methodological quality, 10 SRs were rated as \"critically low\", 13 SRs were rated as \"low\", and 3 SRs were rated as \"moderate\". Exercise was found to exert a beneficial effect on cognitive function, functional independence, physical function, and neuropsychiatric symptoms in patients with AD.</p></div><div><h3>Conclusion</h3><p>Exercise intervention benefits AD patients mainly by improving cognitive function, physical function, functional independence, and neuropsychiatric symptoms. However, due to the low-to-moderate methodology of most SRs included in this analysis, further investigations are required to support our current findings.</p></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000530/pdfft?md5=6b19dab5c6999ffd0847c0b851782207&pid=1-s2.0-S0965229924000530-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Evidence mapping and quality assessment of systematic reviews on exercise intervention for Alzheimer’s disease\",\"authors\":\"Zhengdong Xu , Jiaxing Tang , Wenjuan Yi\",\"doi\":\"10.1016/j.ctim.2024.103065\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>A significant body of literature suggests that exercise can reverse cognitive impairment and ameliorate somatic function in patients with Alzheimer's disease (AD). Systematic reviews (SRs), a common approach of evidence-based medicine, concentrate on a specific issue of a research area. The objective of this work is to provide an overview of existing evidence on the effects of exercise intervention in AD patients and report related health outcomes by reviewing SRs.</p></div><div><h3>Methods</h3><p>SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.</p></div><div><h3>Results</h3><p>A total of 26 SRs met the eligibility criteria. 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引用次数: 0
摘要
背景：大量文献表明，运动可以逆转阿尔茨海默病患者（AD）的认知障碍并改善其躯体功能。系统综述（SR）是循证医学的一种常用方法，主要针对某一研究领域的特定问题。这项工作的目的是通过回顾系统综述，概述运动干预对阿尔茨海默病患者影响的现有证据，并报告相关的健康结果：从PubMed、Cochrane图书馆、CBMdisc、Scopus、Web of Science、Embase（通过Ovid）、中国国家知识基础设施和万方数据库中检索了从开始到2023年2月有关AD患者运动干预的SRs。利用系统综述评估工具 2（AMSTAR 2）检查表评估了系统综述的质量。结果按照人群-干预-比较-结果（PICO）框架进行报告，并通过表格和气泡图说明相应的证据图谱：共有 26 份研究报告符合资格标准。就方法学质量而言，10 篇 SR 被评为 "极低"，13 篇 SR 被评为 "低"，3 篇 SR 被评为 "中等"。研究发现，运动对AD患者的认知功能、功能独立性、身体功能和神经精神症状均有益处：结论：运动干预主要通过改善认知功能、身体功能、功能独立性和神经精神症状来使 AD 患者受益。然而，由于本分析中包含的大多数SR的研究方法都是中低水平的，因此还需要进一步的研究来支持我们目前的发现。
Evidence mapping and quality assessment of systematic reviews on exercise intervention for Alzheimer’s disease
Background
A significant body of literature suggests that exercise can reverse cognitive impairment and ameliorate somatic function in patients with Alzheimer's disease (AD). Systematic reviews (SRs), a common approach of evidence-based medicine, concentrate on a specific issue of a research area. The objective of this work is to provide an overview of existing evidence on the effects of exercise intervention in AD patients and report related health outcomes by reviewing SRs.
Methods
SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.
Results
A total of 26 SRs met the eligibility criteria. In terms of methodological quality, 10 SRs were rated as "critically low", 13 SRs were rated as "low", and 3 SRs were rated as "moderate". Exercise was found to exert a beneficial effect on cognitive function, functional independence, physical function, and neuropsychiatric symptoms in patients with AD.
Conclusion
Exercise intervention benefits AD patients mainly by improving cognitive function, physical function, functional independence, and neuropsychiatric symptoms. However, due to the low-to-moderate methodology of most SRs included in this analysis, further investigations are required to support our current findings.
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