{"title":"使用带有患者上颌牙印模的三维打印设备在狗和猫身上进行微创脑活检：一项初步研究。","authors":"Sabrina Fert, Hadrien Frankar, Alice Dussaux, Clémence Berthomé, Steeve Chantrel, Laurent Cauzinille","doi":"10.2460/ajvr.24.04.0122","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To develop an innovative process for stereotactic brain biopsies in dogs and cats that would provide a definitive diagnosis and optimize the management of patients with brain lesions.</p><p><strong>Animals: </strong>4 dogs and 1 cat diagnosed with 1 or more brain lesion(s) underwent brain biopsies between March 24, 2023, and October 25, 2023.</p><p><strong>Methods: </strong>Based on trajectories selected on images of MRI and CT scan performed on each patient, a computerized software program was used to design a 3-D-printed patient-specific device with maxillary dental impression located on a baseplate to secure the patient's head and with insertion ports for the biopsy instrumentations located on a C-arm. As proof of concept, the device was successfully used in 2 cadavers before being used on clinical patients. All biopsy samples were submitted for histopathological examination.</p><p><strong>Results: </strong>Histological diagnosis was obtained in 80% (4/5) of the cases (choroid plexus tumor, astrocytoma, meningioma, and chronic meningoencephalitis of unknown origin). In 1 patient, the results of biopsy were nondiagnostic; postmortem diagnosis was consistent with a low-grade oligodendroglioma. All the patients were discharged within 24 hours after the procedure without complications. This novel stereotactic system allows the surgeon to perform safe, easy-to-use, inexpensive, and minimally invasive precise brain biopsies in dogs and cats, without complications.</p><p><strong>Clinical relevance: </strong>This unique technique could be applied to any size and type of skull and for any type of brain lesions and would provide diagnostic information that would be valuable for future treatment planning and prognosis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Using a three-dimensional-printed device with the patient's maxillary dental impression allows to perform minimally invasive brain biopsies in dogs and cats: a preliminary study.\",\"authors\":\"Sabrina Fert, Hadrien Frankar, Alice Dussaux, Clémence Berthomé, Steeve Chantrel, Laurent Cauzinille\",\"doi\":\"10.2460/ajvr.24.04.0122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To develop an innovative process for stereotactic brain biopsies in dogs and cats that would provide a definitive diagnosis and optimize the management of patients with brain lesions.</p><p><strong>Animals: </strong>4 dogs and 1 cat diagnosed with 1 or more brain lesion(s) underwent brain biopsies between March 24, 2023, and October 25, 2023.</p><p><strong>Methods: </strong>Based on trajectories selected on images of MRI and CT scan performed on each patient, a computerized software program was used to design a 3-D-printed patient-specific device with maxillary dental impression located on a baseplate to secure the patient's head and with insertion ports for the biopsy instrumentations located on a C-arm. 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引用次数: 0
摘要
目的：为狗和猫的立体定向脑活检开发一种创新流程，以提供明确诊断并优化脑部病变患者的治疗：开发一种创新的犬猫立体定向脑活检流程，为脑部病变患者提供明确诊断并优化管理。动物：在2023年3月24日至2023年10月25日期间，4只犬和1只猫被诊断出患有一个或多个脑部病变，并接受了脑活检：根据在每位患者的核磁共振成像和 CT 扫描图像上选择的轨迹，使用计算机软件程序设计了一种 3-D 打印的患者专用装置，该装置带有上颌牙印模，位于固定患者头部的底板上，并带有位于 C 型臂上的活检器械插入口。作为概念验证，该装置在用于临床患者之前，已在两具尸体上成功使用。所有活检样本均提交组织病理学检查：结果：80%（4/5）的病例获得了组织学诊断（脉络丛肿瘤、星形细胞瘤、脑膜瘤和不明原因的慢性脑膜脑炎）。有一名患者的活检结果无法确诊，死后诊断为低级别少突胶质细胞瘤。所有患者均在术后 24 小时内出院，未出现并发症。这种新型立体定向系统可让外科医生对猫狗进行安全、易用、廉价和微创的精确脑活检，且无并发症：这项独特的技术可用于任何大小和类型的头骨以及任何类型的脑损伤，并可提供对未来治疗计划和预后有价值的诊断信息。
Using a three-dimensional-printed device with the patient's maxillary dental impression allows to perform minimally invasive brain biopsies in dogs and cats: a preliminary study.
Objective: To develop an innovative process for stereotactic brain biopsies in dogs and cats that would provide a definitive diagnosis and optimize the management of patients with brain lesions.
Animals: 4 dogs and 1 cat diagnosed with 1 or more brain lesion(s) underwent brain biopsies between March 24, 2023, and October 25, 2023.
Methods: Based on trajectories selected on images of MRI and CT scan performed on each patient, a computerized software program was used to design a 3-D-printed patient-specific device with maxillary dental impression located on a baseplate to secure the patient's head and with insertion ports for the biopsy instrumentations located on a C-arm. As proof of concept, the device was successfully used in 2 cadavers before being used on clinical patients. All biopsy samples were submitted for histopathological examination.
Results: Histological diagnosis was obtained in 80% (4/5) of the cases (choroid plexus tumor, astrocytoma, meningioma, and chronic meningoencephalitis of unknown origin). In 1 patient, the results of biopsy were nondiagnostic; postmortem diagnosis was consistent with a low-grade oligodendroglioma. All the patients were discharged within 24 hours after the procedure without complications. This novel stereotactic system allows the surgeon to perform safe, easy-to-use, inexpensive, and minimally invasive precise brain biopsies in dogs and cats, without complications.
Clinical relevance: This unique technique could be applied to any size and type of skull and for any type of brain lesions and would provide diagnostic information that would be valuable for future treatment planning and prognosis.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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