Li Ma, Yilong Yao, Xiong Zhao, Junsheng Hou, Lei Huang, Zihan Ding, Xinlan Lu, Jinjia Wei and Nanjing Hao*,
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引用次数: 0
摘要
水凝胶微球是一种生物相容性材料,广泛应用于生物和医疗领域。乳化和搅拌是制备水凝胶的常用方法。但其粒度分布较广,单分散性和机械强度较差,稳定操作条件相对狭窄,难以满足一些复杂的应用。本文开发了一种结合简单侧微通道结构的 T 型阶梯式微通道,以探索液-液分散机理、界面演化行为、卫星液滴形成机理和分离,并最终成功合成右旋糖酐水凝胶微球。全面研究了操作参数对液滴和微球尺寸的影响。给出了流动模式和稳定操作条件范围,并建立了三种不同流动状态下的液滴粒度预测数学模型。在稳定操作条件的基础上,开发了一种基于微液滴并结合紫外光固化的方法来合成葡聚糖水凝胶微球。在所开发的微流控平台上合成了高度均匀、单分散且具有良好机械强度的葡聚糖微球。微球的尺寸可在 50 到 300 μm 之间调节,毛细管数在 0.006-0.742 之间。这项工作不仅为功能性聚合物微球的制备提供了简便的方法,还为开发坚固耐用的微反应器提供了重要的设计指南。
Rational Design of Liquid–Liquid Microdispersion Droplet Microreactors for the Controllable Synthesis of Highly Uniform and Monodispersed Dextran Microspheres
Hydrogel microspheres are biocompatible materials widely used in biological and medical fields. Emulsification and stirring are the commonly used methods to prepare hydrogels. However, the size distribution is considerably wide, the monodispersity and the mechanical intensity are poor, and the stable operation conditions are comparatively narrow to meet some sophisticated applications. In this paper, a T-shaped stepwise microchannel combined with a simple side microchannel structure is developed to explore the liquid–liquid dispersion mechanism, interfacial evolution behavior, satellite droplet formation mechanism and separation, and the eventual successful synthesis of dextran hydrogel microspheres. The effect of the operation parameters on droplet and microsphere size is comprehensively studied. The flow pattern and the stable operation condition range are given, and mathematical prediction models are developed under three different flow regimes for droplet size prediction. Based on the stable operating conditions, a microdroplet-based method combined with UV light curing is developed to synthesize the dextran hydrogel microsphere. The highly uniform and monodispersed dextran microspheres with good mechanical intensity are synthesized in the developed microfluidic platform. The size of the microsphere could be tuned from 50 to 300 μm with a capillary number in the range of 0.006–0.742. This work not only provides a facile method for functional polymeric microsphere preparation but also offers important design guidelines for the development of a robust microreactor.
期刊介绍:
Langmuir is an interdisciplinary journal publishing articles in the following subject categories:
Colloids: surfactants and self-assembly, dispersions, emulsions, foams
Interfaces: adsorption, reactions, films, forces
Biological Interfaces: biocolloids, biomolecular and biomimetic materials
Materials: nano- and mesostructured materials, polymers, gels, liquid crystals
Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry
Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals
However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do?
Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*.
This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).