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探索 miRNA 的产生过程及其结构规则

IF 15.8 1区 生物学 Q1 PLANT SCIENCES
Nature Plants Pub Date : 2024-07-02 DOI:10.1038/s41477-024-01728-6
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引用次数: 0

摘要

对半活性 DCL1 突变体进行降解组测序，将拟南芥中真正的 miRNA 与不依赖 DCL1 的小 RNA 区分开来，并说明了 147 个 pri-miRNA 的加工模式。与此同时，DMS-MaPseq 对 pri-miRNA 的体内二级结构进行了解码，从而更好地了解了裂解模式以及 DCL1 辅因子对裂解的影响。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring the landscape of miRNA production and the structural rules that shape it

Exploring the landscape of miRNA production and the structural rules that shape it

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Exploring the landscape of miRNA production and the structural rules that shape it
Degradome sequencing of semi-active DCL1 mutants separates true miRNAs from DCL1-independent small RNAs in Arabidopsis thaliana and illustrates the processing pattern of 147 pri-miRNAs. In parallel, DMS-MaPseq decodes the in vivo secondary structures of pri-miRNAs, enabling a better understanding of cleavage modes and of the impact of DCL1 cofactors on cleavage.
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来源期刊
Nature Plants
Nature Plants PLANT SCIENCES-
CiteScore
25.30
自引率
2.20%
发文量
196
期刊介绍： Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.
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