Sarah Wirth, Annika Schlößer, Antonia Beiersdorfer, Michaela Schweizer, Marcel S. Woo, Manuel A. Friese, Christian Lohr, Katarzyna M. Grochowska
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引用次数: 0
摘要
封面插图:神经胶质纤维酸性蛋白(GFAP;火烧查找表,颜色亮度与像素强度成正比)是一种中间丝蛋白,它的上调是与阿尔茨海默病(AD)病理相关的星形胶质细胞反应性的标志。用一种改良形式的淀粉样蛋白-β(Aβ3(pE)- 42)处理培养的星形胶质细胞会导致突出的 GFAP 上调。(见 Wirth, S. 等人,https://doi.org/10.1002/glia.24539)
Cover Illustration: The upregulation of glial fibrillary acidic protein (GFAP; fire lookup table, the brightness of the color is proportional to the pixel intensity), an intermediate filament protein, is a marker of astrocytic reactivity associated with Alzheimer's disease (AD) pathology. The treatment of cultured astrocytes with a modified form of amyloid-β, Aβ3(pE)- 42, leads to the prominent GFAP upregulation. (See Wirth, S., et al, https://doi.org/10.1002/glia.24539)
期刊介绍:
GLIA is a peer-reviewed journal, which publishes articles dealing with all aspects of glial structure and function. This includes all aspects of glial cell biology in health and disease.