核酸结合 KH 结构域蛋白影响一系列生物通路,包括作为膜定位复合物的一部分发挥作用

IF 3.5 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Md Kamrul Hasan , L. Jeannine Brady
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引用次数: 0

摘要

K-Homology 结构域(KH 结构域)蛋白质结合单链核酸,影响包藏它们的蛋白质之间的相互作用,在所有生命体中都有发现。KH 结构域与其他功能蛋白结构域共同参与各种关键的生物活动,通常是在包括膜定位蛋白复合物在内的高阶机制中发挥作用。真核生物的 KH 结构域蛋白与发育过程、形态发生和生长调节有关,它们的异常表达往往与癌症有关。原核生物的 KH 结构域蛋白参与细胞整体活动,包括细胞分裂和蛋白质转运。真核生物和原核生物的 KH 结构域具有相同的结构特征,但根据其结构组织不同而有所区别。在本综述中,我们将探讨已知 KH 结构域蛋白质的结构/功能关系,并重点介绍它们在膜内或膜表面发挥作用的情况。我们还总结了影响细菌毒力和致病机理的 KH 结构域蛋白实例。最后,我们讨论了为更好地研究这一类在很大程度上未被充分研究的蛋白质而可能采取的研究途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes

Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes

K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence protein–protein interactions of proteins that harbor them, and are found in all kingdoms of life. In concert with other functional protein domains KH domains contribute to a variety of critical biological activities, often within higher order machineries including membrane-localized protein complexes. Eukaryotic KH domain proteins are linked to developmental processes, morphogenesis, and growth regulation, and their aberrant expression is often associated with cancer. Prokaryotic KH domain proteins are involved in integral cellular activities including cell division and protein translocation. Eukaryotic and prokaryotic KH domains share structural features, but are differentiated based on their structural organizations. In this review, we explore the structure/function relationships of known examples of KH domain proteins, and highlight cases in which they function within or at membrane surfaces. We also summarize examples of KH domain proteins that influence bacterial virulence and pathogenesis. We conclude the article by discussing prospective research avenues that could be pursued to better investigate this largely understudied protein category.

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来源期刊
Journal of Structural Biology: X
Journal of Structural Biology: X Biochemistry, Genetics and Molecular Biology-Structural Biology
CiteScore
6.50
自引率
0.00%
发文量
20
审稿时长
62 days
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