Linda E. Chanamé Pinedo , Anouk P. Meijs , Huifang Deng , Sabine C. de Greeff , Engeline van Duijkeren , Cindy M. Dierikx , Kees T. Veldman , Pim Sanders , Maaike J.C. van den Beld , Bart Wullings , Eelco Franz , Roan Pijnacker , Lapo Mughini-Gras
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The focus was on <em>Salmonella</em> Enteritidis (SE) and <em>Salmonella</em> Typhimurium including its monophasic variant (ST/STM).</p></div><div><h3>Methods</h3><p>A national population registry-based study was conducted in the Netherlands from 2008 to 2019. Multivariable logistic regression models were used to assess the associations between livestock AMU and NTS resistance proportion in humans and broilers/pigs, overall as well as per class-specific antimicrobials. Correlation analysis was performed to relate AMR proportions between human and broiler/pig NTS isolates.</p></div><div><h3>Results</h3><p>For SE, only a positive association between penicillins use in broilers and resistance to ampicillin among human isolates was significant. For ST/STM, most associations between AMU in livestock and AMR among human isolates were significantly positive, overall and per class-specific antimicrobials, namely for penicillins-ampicillin, tetracyclines-tetracycline and sulfonamides/trimethoprim-sulfamethoxazole/trimethoprim. Significantly positive associations between AMU in broilers/pigs and AMR in broiler/pig ST/STM isolates were also observed, but not between broiler/pig and human AMR levels.</p></div><div><h3>Conclusions</h3><p>Significant associations were generally found between livestock AMU and AMR in human and broiler/pig ST/STM isolates. However, confounding factors, such as imported meat and travel are of concern. To fully comprehend the impact of livestock AMU on resistance in human NTS isolates, it is imperative to enhance AMR surveillance of NTS.</p></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352771424001708/pdfft?md5=78d4b6283769cbfdb760faff40598245&pid=1-s2.0-S2352771424001708-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Temporal association of antimicrobial use in livestock with antimicrobial resistance in non-typhoid Salmonella human infections in the Netherlands, 2008–2019\",\"authors\":\"Linda E. Chanamé Pinedo , Anouk P. Meijs , Huifang Deng , Sabine C. de Greeff , Engeline van Duijkeren , Cindy M. Dierikx , Kees T. Veldman , Pim Sanders , Maaike J.C. van den Beld , Bart Wullings , Eelco Franz , Roan Pijnacker , Lapo Mughini-Gras\",\"doi\":\"10.1016/j.onehlt.2024.100844\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Antimicrobial use (AMU) in livestock contributes to antimicrobial resistance (AMR) among zoonotic pathogens, such as non-typhoid <em>Salmonella</em> (NTS). Since 2009, the Netherlands has made substantial efforts to reduce AMU in livestock.</p></div><div><h3>Objectives</h3><p>To assess the association between AMU in livestock and AMR in NTS human isolates. Additionally, associations between AMU in broilers/pigs and AMR in NTS broiler/pig isolates, and between AMR in broilers/pigs and in human NTS isolates were assessed. The focus was on <em>Salmonella</em> Enteritidis (SE) and <em>Salmonella</em> Typhimurium including its monophasic variant (ST/STM).</p></div><div><h3>Methods</h3><p>A national population registry-based study was conducted in the Netherlands from 2008 to 2019. Multivariable logistic regression models were used to assess the associations between livestock AMU and NTS resistance proportion in humans and broilers/pigs, overall as well as per class-specific antimicrobials. Correlation analysis was performed to relate AMR proportions between human and broiler/pig NTS isolates.</p></div><div><h3>Results</h3><p>For SE, only a positive association between penicillins use in broilers and resistance to ampicillin among human isolates was significant. For ST/STM, most associations between AMU in livestock and AMR among human isolates were significantly positive, overall and per class-specific antimicrobials, namely for penicillins-ampicillin, tetracyclines-tetracycline and sulfonamides/trimethoprim-sulfamethoxazole/trimethoprim. Significantly positive associations between AMU in broilers/pigs and AMR in broiler/pig ST/STM isolates were also observed, but not between broiler/pig and human AMR levels.</p></div><div><h3>Conclusions</h3><p>Significant associations were generally found between livestock AMU and AMR in human and broiler/pig ST/STM isolates. However, confounding factors, such as imported meat and travel are of concern. 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引用次数: 0
摘要
背景家畜使用抗菌药（AMU）会导致人畜共患病病原体（如非伤寒沙门氏菌（NTS））产生抗菌药耐药性（AMR）。自 2009 年以来，荷兰在减少家畜 AMU 方面做出了巨大努力。目的 评估家畜 AMU 与人类 NTS 分离物中 AMR 之间的关联。此外，还评估了肉鸡/猪中的 AMU 与肉鸡/猪 NTS 分离物中的 AMR 之间的关系，以及肉鸡/猪中的 AMR 与人类 NTS 分离物中的 AMR 之间的关系。研究重点是肠炎沙门氏菌（SE）和鼠伤寒沙门氏菌，包括其单相变种（ST/STM）。方法 2008 年至 2019 年在荷兰开展了一项基于全国人口登记的研究。采用多变量逻辑回归模型来评估家畜AMU与人类和肉鸡/猪的NTS耐药性比例之间的关系，包括总体耐药性和每类抗菌药物的耐药性。结果 就 SE 而言，只有肉鸡使用青霉素与人类分离物对氨苄西林的耐药性之间存在显著的正相关。就 ST/STM 而言，牲畜中的 AMU 与人类分离物中的 AMR 之间的关系大多呈显著正相关，包括总体关系和每类特定抗菌药物的关系，即青霉素-氨苄西林、四环素-四环素和磺胺类药物/三甲氧苄青霉素-磺胺甲恶唑/三甲氧苄青霉素。肉鸡/猪的 AMU 与肉鸡/猪 ST/STM 分离物中的 AMR 之间也存在显著的正相关关系，但肉鸡/猪与人类 AMR 水平之间不存在正相关关系。然而，进口肉类和旅行等混杂因素也值得关注。为了充分了解家畜AMU对人类NTS分离物耐药性的影响，必须加强对NTS的AMR监测。
Temporal association of antimicrobial use in livestock with antimicrobial resistance in non-typhoid Salmonella human infections in the Netherlands, 2008–2019
Background
Antimicrobial use (AMU) in livestock contributes to antimicrobial resistance (AMR) among zoonotic pathogens, such as non-typhoid Salmonella (NTS). Since 2009, the Netherlands has made substantial efforts to reduce AMU in livestock.
Objectives
To assess the association between AMU in livestock and AMR in NTS human isolates. Additionally, associations between AMU in broilers/pigs and AMR in NTS broiler/pig isolates, and between AMR in broilers/pigs and in human NTS isolates were assessed. The focus was on Salmonella Enteritidis (SE) and Salmonella Typhimurium including its monophasic variant (ST/STM).
Methods
A national population registry-based study was conducted in the Netherlands from 2008 to 2019. Multivariable logistic regression models were used to assess the associations between livestock AMU and NTS resistance proportion in humans and broilers/pigs, overall as well as per class-specific antimicrobials. Correlation analysis was performed to relate AMR proportions between human and broiler/pig NTS isolates.
Results
For SE, only a positive association between penicillins use in broilers and resistance to ampicillin among human isolates was significant. For ST/STM, most associations between AMU in livestock and AMR among human isolates were significantly positive, overall and per class-specific antimicrobials, namely for penicillins-ampicillin, tetracyclines-tetracycline and sulfonamides/trimethoprim-sulfamethoxazole/trimethoprim. Significantly positive associations between AMU in broilers/pigs and AMR in broiler/pig ST/STM isolates were also observed, but not between broiler/pig and human AMR levels.
Conclusions
Significant associations were generally found between livestock AMU and AMR in human and broiler/pig ST/STM isolates. However, confounding factors, such as imported meat and travel are of concern. To fully comprehend the impact of livestock AMU on resistance in human NTS isolates, it is imperative to enhance AMR surveillance of NTS.
期刊介绍：
One Health - a Gold Open Access journal.
The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information.
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