视网膜器官组织在眼科再生医学中的应用：微型综述

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.06.013

Xinmei Lan , Huixia Jiang , Qian Wang, Qin Shiqi, Yu Xiong

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引用次数: 0

摘要

视网膜器官组织是由干细胞或祖细胞在体外诱导分化而成的三维（3D）显微组织，其结构与视网膜高度相似。随着三维视网膜培养体系的优化和发展以及诱导分化技术的提高，视网膜器官组织在视网膜发育、再生医学、生物材料评估、疾病机理研究和药物筛选等方面具有广阔的应用前景。在这篇综述中，我们总结了视网膜器官组织的最新发展及其在眼科再生医学中的应用。我们特别强调了视网膜器官组织在疾病建模和药物发现中的应用前景和挑战。

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The application of retinal organoids in ophthalmic regenerative medicine: A mini-review

Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to the retina. With the optimization and development of 3D retinal culture system and the improvement of induced differentiation technology, retinal organoids have broad application prospects in retinal development, regenerative medicine, biomaterial evaluation, disease mechanism investigation, and drug screening. In this review we summarize recent development of retinal organoids and their applications in ophthalmic regenerative medicine. In particular, we highlight the promise and challenges in the use of retinal organoids in disease modeling and drug discovery.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.