制药业务中数字应用的未来

IF 8 2区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Current Opinion in Chemical Engineering Pub Date : 2024-06-29 DOI:10.1016/j.coche.2024.101038

Constantinos C Pantelides, Frances E Pereira

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引用次数: 0

摘要

数字应用程序（DA）是用于决策支持和工艺操作控制的在线/实时软件系统。它们利用从先前的科学和工程知识中得出的精确模型，结合工厂数据，提供卓越的工艺性能。本文回顾了用于制药操作中开环过程监控和闭环控制的 DAs 的最新发展，并分析了 DAs 对底层数学模型提出的要求。文章还讨论了要在制药行业大规模应用这些技术需要克服的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The future of digital applications in pharmaceutical operations

Digital applications (DAs) are online/real-time software systems for decision support and control of process operations. They deliver superior process performance by drawing on accurate models derived from prior scientific and engineering knowledge, combined with plant data. This article reviews recent developments on DAs for open-loop process monitoring and closed-loop control in pharmaceutical operations and analyzes the requirements that they pose on the underlying mathematical models. It also discusses the challenges that need to be overcome to allow their deployment at scale in the pharmaceutical sector.

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来源期刊

Current Opinion in Chemical Engineering BIOTECHNOLOGY & APPLIED MICROBIOLOGYENGINE-ENGINEERING, CHEMICAL

CiteScore

12.80

自引率

3.00%

发文量

114

期刊介绍： Current Opinion in Chemical Engineering is devoted to bringing forth short and focused review articles written by experts on current advances in different areas of chemical engineering. Only invited review articles will be published. The goals of each review article in Current Opinion in Chemical Engineering are: 1. To acquaint the reader/researcher with the most important recent papers in the given topic. 2. To provide the reader with the views/opinions of the expert in each topic. The reviews are short (about 2500 words or 5-10 printed pages with figures) and serve as an invaluable source of information for researchers, teachers, professionals and students. The reviews also aim to stimulate exchange of ideas among experts. Themed sections: Each review will focus on particular aspects of one of the following themed sections of chemical engineering: 1. Nanotechnology 2. Energy and environmental engineering 3. Biotechnology and bioprocess engineering 4. Biological engineering (covering tissue engineering, regenerative medicine, drug delivery) 5. Separation engineering (covering membrane technologies, adsorbents, desalination, distillation etc.) 6. Materials engineering (covering biomaterials, inorganic especially ceramic materials, nanostructured materials). 7. Process systems engineering 8. Reaction engineering and catalysis.